1. Home
  2. Analysis
  3. Wellbutrin-xl
  4. Osteoporosis

Wellbutrin xl and Osteoporosis - a phase IV clinical study of FDA data

Summary:

Osteoporosis is reported as a side effect among people who take Wellbutrin xl (bupropion hydrochloride), especially for people who are female, 50-59 old, have been taking the drug for 10+ years also take Nexium, and have Metastases to bone.

The phase IV clinical study analyzes which people have Osteoporosis when taking Wellbutrin xl. It is created by eHealthMe based on reports of 18,200 people who have side effects when taking Wellbutrin xl from the FDA, and is updated regularly.

What is Wellbutrin xl?

Wellbutrin xl has active ingredients of bupropion hydrochloride. It is often used in depression. eHealthMe is studying from 23,002 Wellbutrin xl users. Check the latest studies of Wellbutrin xl.

What is Osteoporosis?

Osteoporosis (bones weak and more likely to break) is found to be associated with 1,806 drugs and 1,905 conditions by eHealthMe. Check the latest studies of Osteoporosis.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

18,200 people reported to have side effects when taking Wellbutrin xl.
Among them, 82 people (0.45%) have Osteoporosis.

Could Wellbutrin xl cause Osteoporosis?

Among these 82 people:

How long have people been on Wellbutrin xl when they have Osteoporosis? *

  • < 1 month: 0.0 %
  • 1 - 6 months: 50 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 50 %

What is the gender of people who have Osteoporosis when taking Wellbutrin xl? *

  • female: 79.01 %
  • male: 20.99 %

What is the age of people who have Osteoporosis when taking Wellbutrin xl? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 1.54 %
  • 20-29: 0.0 %
  • 30-39: 10.77 %
  • 40-49: 4.62 %
  • 50-59: 53.85 %
  • 60+: 29.23 %

What are other drugs people take besides Wellbutrin xl? *

  1. Nexium: 34 people, 41.46%
  2. Gabapentin: 30 people, 36.59%
  3. Prilosec: 28 people, 34.15%
  4. Prozac: 27 people, 32.93%
  5. Celebrex: 22 people, 26.83%
  6. Protonix: 22 people, 26.83%
  7. Cymbalta: 22 people, 26.83%
  8. Ambien: 21 people, 25.61%
  9. Celexa: 20 people, 24.39%
  10. Simvastatin: 20 people, 24.39%

What are other side effects people have besides Osteoporosis? *

  1. Pain: 38 people, 46.34%
  2. Fall: 32 people, 39.02%
  3. Osteoarthritis (a joint disease caused by cartilage loss in a joint): 27 people, 32.93%
  4. Memory Loss: 25 people, 30.49%
  5. Nausea (feeling of having an urge to vomit): 24 people, 29.27%
  6. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 24 people, 29.27%
  7. Osteopenia (a condition where bone mineral density is lower than normal): 23 people, 28.05%
  8. Spinal Osteoarthritis (joint cartilage loss in spine): 22 people, 26.83%
  9. Back Pain: 22 people, 26.83%
  10. Bone Disorder: 22 people, 26.83%

What are the existing conditions these people have? *

  1. Metastases To Bone (cancer spreads to bone): 14 people, 17.07%
  2. High Blood Pressure: 12 people, 14.63%
  3. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 12 people, 14.63%
  4. Hiv Infection: 7 people, 8.54%
  5. Pain: 7 people, 8.54%
  6. Irritable Bowel Syndrome: 6 people, 7.32%
  7. High Blood Cholesterol: 6 people, 7.32%
  8. Breast Cancer Metastatic: 6 people, 7.32%
  9. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 5 people, 6.10%
  10. Immunodeficiency Common Variable: 5 people, 6.10%

* Approximation only. Some reports may have incomplete information.

Do you take Wellbutrin xl and have Osteoporosis?

- Check whether Osteoporosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Wellbutrin xl:

Osteoporosis treatments and more:

How severe was Osteoporosis and when was it recovered:

Expand to all the drugs that have ingredients of bupropion hydrochloride:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Wellbutrin xl:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Osteoporosis:

Browse all the conditions that are associated with Osteoporosis:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on bupropion hydrochloride (the active ingredients of Wellbutrin xl) and Wellbutrin xl (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

Recent studies on eHealthMe:

© 2026 eHealthMe.com. All rights reserved. Use of this site constitutes acceptance of eHealthMe.com's terms of service and privacy policy.