Zanaflex and Sciatica - a phase IV clinical study of FDA data

Summary:

Sciatica is reported as a side effect among people who take Zanaflex (tizanidine hydrochloride), especially for people who are female, 50-59 old, have been taking the drug for 2 - 5 years also take Ambien, and have Multiple myeloma.

The phase IV clinical study analyzes which people have Sciatica when taking Zanaflex. It is created by eHealthMe based on reports of 16,325 people who have side effects when taking Zanaflex from the FDA, and is updated regularly.

What is Zanaflex?

Zanaflex has active ingredients of tizanidine hydrochloride. It is often used in muscle spasms. eHealthMe is studying from 17,474 Zanaflex users. Check the latest studies of Zanaflex.

What is Sciatica?

Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve) is found to be associated with 1,152 drugs and 1,415 conditions by eHealthMe. Check the latest studies of Sciatica.

On Jul, 31, 2025

16,325 people reported to have side effects when taking Zanaflex.
Among them, 80 people (0.49%) have Sciatica.

Among these 80 people:

How long have people been on Zanaflex when they have Sciatica? *

What is the gender of people who have Sciatica when taking Zanaflex? *

female: 61.84 %
male: 38.16 %

What is the age of people who have Sciatica when taking Zanaflex? *

What are other drugs people take besides Zanaflex? *

What are other side effects people have besides Sciatica? *

Back Pain: 37 people, 46.25%
Stress And Anxiety: 30 people, 37.50%
Joint Pain: 29 people, 36.25%
Haematochezia (passage of stools containing blood): 24 people, 30.00%
Exostosis (formation of new bone on the surface of a bone): 23 people, 28.75%
Chest Pain: 22 people, 27.50%
Osteonecrosis Of Jaw (death of bone of jaw): 22 people, 27.50%
Gait Disturbance: 21 people, 26.25%
Fatigue (feeling of tiredness): 21 people, 26.25%
Nausea (feeling of having an urge to vomit): 21 people, 26.25%

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 14 people, 17.50%
Multiple Myeloma (cancer of the plasma cells): 14 people, 17.50%
Dyspnea (difficult or laboured breathing): 13 people, 16.25%
Osteoporosis (bones weak and more likely to break): 11 people, 13.75%
Osteopenia (a condition where bone mineral density is lower than normal): 10 people, 12.50%
High Blood Cholesterol: 10 people, 12.50%
Arthropod Sting (arthropod bite): 9 people, 11.25%
Breast Cancer: 7 people, 8.75%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 7.50%
Depression: 6 people, 7.50%

* Approximation only. Some reports may have incomplete information.

Do you take Zanaflex and have Sciatica?

- Check whether Sciatica is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zanaflex:

Zanaflex (17,474 reports)

Sciatica treatments and more:

Sciatica (28,503 reports)

Browse all side effects of Zanaflex:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Sciatica:

Sciatica (1,152 drugs)

Browse all the conditions that are associated with Sciatica:

Sciatica (1,415 conditions)

Drugs similar to Zanaflex and Sciatica :

How the study uses the data?

The study uses data from the FDA. It is based on tizanidine hydrochloride (the active ingredients of Zanaflex) and Zanaflex (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.