Retinal degeneration and drugs of ingredients of bupropion hydrochloride (a real world drug study)


Summary:

Retinal degeneration is found among people who take drugs with ingredients of bupropion hydrochloride, especially for people who are female, 60+ old , have been taking the drugs for 1 - 2 years. This phase IV clinical study is created by eHealthMe based on reports of 179,375 people who have side effects when taking drugs with ingredients of bupropion hydrochloride from the FDA, and is updated regularly.

Drug(s) considered in the study (i.e. both brand name and generic drugs): Aplenzin, Bupropion hydrobromide, Bupropion hydrochloride, Forfivo xl, Wellbutrin, Wellbutrin sr, Wellbutrin xl, Zyban.


On Aug, 01, 2026

179,375 people reported to have side effects when taking drugs with ingredients of bupropion hydrochloride.
Among them, 16 people (0.01%) have Retinal degeneration


What is Retinal degeneration?

Retinal degeneration (death of the cells of the retina) is found to be associated with 160 drugs and 316 conditions by eHealthMe. Check the latest studies of Retinal degeneration.

Number of reports submitted per year:

Could drugs with ingredients of bupropion hydrochloride cause Retinal degeneration?

Time on drugs with ingredients of bupropion hydrochloride when people have Retinal degeneration *:

  • < 1 month: 0.0 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 100 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Retinal degeneration when taking drugs with ingredients of bupropion hydrochloride *:

  • female: 53.85 %
  • male: 46.15 %

Age of people who have Retinal degeneration when taking drugs with ingredients of bupropion hydrochloride *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 20 %
  • 20-29: 0.0 %
  • 30-39: 30 %
  • 40-49: 0.0 %
  • 50-59: 10 %
  • 60+: 40 %

Conditions people have *:

You may use this to check any potential undetected conditions.

  1. Cystitis Interstitial (unknown cause characterized by bladder pain): 4 people, 25.00%
  2. Sleep Disorder: 3 people, 18.75%
  3. Nausea (feeling of having an urge to vomit): 3 people, 18.75%
  4. Gastric Disorder (disease of stomach): 3 people, 18.75%
  5. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 18.75%
  6. High Blood Pressure: 2 people, 12.50%
  7. Dermatomyositis (inflammation of the skin and underlying muscle tissue, typically occurring as an autoimmune condition or associated with internal cancer): 2 people, 12.50%
  8. Diabetic Retinal Oedema (excessive build-up of fluid in the retina due to diabetes): 2 people, 12.50%
  9. Diabetic Retinopathy (damage to the retina caused by complications of diabetes): 2 people, 12.50%
  10. Gastric Ulcer (stomach ulcer): 2 people, 12.50%

Other drugs people take *:

You may use this to check any potential interacting drugs.

  1. Lucentis: 4 people, 25.00%
  2. Avastin: 4 people, 25.00%
  3. Elmiron: 4 people, 25.00%
  4. Pantoprazole: 4 people, 25.00%
  5. Aripiprazole: 3 people, 18.75%
  6. Klor-Con: 2 people, 12.50%
  7. Zolpidem: 2 people, 12.50%
  8. Lotrel: 2 people, 12.50%
  9. Losartan Potassium: 2 people, 12.50%
  10. Lipitor: 2 people, 12.50%

Other side effects people have besides Retinal degeneration *:

You may use this to check any potential undetected side effects.

  1. Visual Acuity Reduced (reduced clearness of vision): 4 people, 25.00%
  2. Macular Oedema (fluid and protein deposits collect on or under the macula of the eye (a yellow central area of the retina) and causes it to thicken): 4 people, 25.00%
  3. Maculopathy (a condition or disease of the macula, the small spot in the retina where vision is keenest): 4 people, 25.00%
  4. Metamorphopsia (a type of distorted vision in which a grid of straight lines appears wavy and parts of the grid may appear blank): 4 people, 25.00%
  5. Vitreous Floaters (spots before the eyes): 3 people, 18.75%
  6. Vision Blurred: 3 people, 18.75%
  7. Eye Pain: 3 people, 18.75%
  8. Retinal Haemorrhage (bleeding from retina): 3 people, 18.75%
  9. Photopsia (presence of perceived flashes of light): 2 people, 12.50%
  10. Blood Glucose Fluctuation: 2 people, 12.50%

* Approximation only. Some reports may have incomplete information.


How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Related studies

Drugs with ingredients of bupropion hydrochloride, their effectiveness, alternatives and more:

How the study uses the data?

The study uses data from the FDA. It is based on bupropion hydrochloride. All drugs that have the same active ingredients (e.g. brand name and generic drugs) are considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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