Wellbutrin and Prozac drug interactions for men aged 60+ (a phase IV clinical study of FDA data)
Summary:
Drug interactions are found for men aged 60+ who take Wellbutrin (bupropion hydrochloride) and Prozac (fluoxetine hydrochloride) together. We list drug interactions by the duration when the drugs are taken. This phase IV study is created by eHealthMe based on reports of 154 people from the FDA, and is updated regularly.
eHealthMe: drug outcomes in the real world
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154 men aged 60+ who take Wellbutrin, Prozac and have drug interactions are studied.
What is Wellbutrin?
Wellbutrin has active ingredients of bupropion hydrochloride. It is often used in depression. eHealthMe is studying from 117,110 Wellbutrin users. Check the latest studies of Wellbutrin.
What is Prozac?
Prozac has active ingredients of fluoxetine hydrochloride. It is often used in depression. eHealthMe is studying from 82,988 Prozac users. Check the latest studies of Prozac.
Number of reports submitted per year:

Most common drug interactions over time *:
< 1 month:
- Delirium (wild excitement)
- Hyperglycaemia (high blood sugar)
- Asthenia (weakness)
- Fatigue (feeling of tiredness)
1 - 6 months:
- Suicidal ideation
- Agitation (state of anxiety or nervous excitement)
- Balance disorder
- Insomnia (sleeplessness)
6 - 12 months:
n/a
1 - 2 years:
- Chronic kidney disease
- Fall
- Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
- Lung adenocarcinoma metastatic (a form of non-small cell lung cancer spreads to other part)
- Pain in extremity
- Renal failure (kidney dysfunction)
- Seizure (abnormal excessive or synchronous neuronal activity in the brain)
2 - 5 years:
n/a
5 - 10 years:
n/a
10+ years:
n/a
not specified:
- Insomnia (sleeplessness)
- Abdominal distension
- Abdominal pain upper
- Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
- Anaemia (lack of blood)
- Anaphylactic shock (severe and rapid and sometimes fatal hypersensitivity reaction to a substance)
- Atrioventricular block complete (heart block complete)
- Back pain
- Blood creatine phosphokinase increased
- Bone pain
* Approximation only. Some reports may have incomplete information.
Do you take Wellbutrin and Prozac?
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How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Related studies:
How the study uses the data?
The study is based on (applicable) gender, age, bupropion hydrochloride and fluoxetine hydrochloride (the active ingredients of Wellbutrin and Prozac, respectively), and Wellbutrin and Prozac (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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