Acetaminophen and codeine phosphate and Codeine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Acetaminophen and codeine phosphate (acetaminophen; codeine phosphate) and Codeine (codeine sulfate). Common drug interactions include depression among females and acidosis among males.

The phase IV clinical study analyzes what interactions people have when they take Acetaminophen and codeine phosphate and Codeine. It is created by eHealthMe based on reports of 32 people who take the same drugs from the FDA, and is updated regularly.

What is Acetaminophen and codeine phosphate?

Acetaminophen and codeine phosphate has active ingredients of acetaminophen; codeine phosphate. It is often used in pain. eHealthMe is studying from 3,220 Acetaminophen and codeine phosphate users. Check the latest studies of Acetaminophen and codeine phosphate.

What is Codeine?

Codeine has active ingredients of codeine sulfate. It is often used in pain. eHealthMe is studying from 42,342 Codeine users. Check the latest studies of Codeine.

On Jul, 08, 2026

32 people who take Acetaminophen and codeine phosphate and Codeine together, and have interactions are studied.

Acetaminophen and codeine phosphate and Codeine drug interactions.

What are the common drug interactions of Acetaminophen And Codeine Phosphate and Codeine, by gender? *:

female:

Depression
Drug eruption (adverse drug reaction of the skin)
Joint swelling
Pruritus (severe itching of the skin)
Arthropathy
Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Chills (felling of cold)
Dysphonia (speech disorder attributable to a disorder of phonation)
Ear pruritus (pruritus or itching is ""the unpleasant skin sensation that frequently provokes scratching"" in ear)

male:

Acidosis (build-up of carbon dioxide in the blood)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Anaemia (lack of blood)
Apnoea (suspension of external breathing)
Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
Arthralgia (joint pain)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Blood pressure decreased
Cardiac failure
Cardiovascular insufficiency (inadequate functioning of heart)

What are the common drug interactions of Acetaminophen And Codeine Phosphate and Codeine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Apnoea (suspension of external breathing)
Headache (pain in head)
Hepatosplenomegaly (enlargement of both the liver and the spleen)
Pain in jaw
Pulmonary oedema (fluid accumulation in the lungs)
Pyrexia (fever)
Snoring
Ulcer
Unresponsive to stimuli

20-29:

n/a

30-39:

Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
Cardiovascular insufficiency (inadequate functioning of heart)
Conjunctival hyperaemia (congestion of conjunctival vessels)
Contusion (a type of hematoma of tissue in which capillaries)
Depressed level of consciousness
Drug toxicity
Epistaxis (bleed from the nose)
Excoriation (to tear or wear off the skin of)
Injury
Mouth haemorrhage (bleeding from mouth)

40-49:

Depression

50-59:

Drug eruption (adverse drug reaction of the skin)
Joint swelling
Malaise (a feeling of general discomfort or uneasiness)

60+:

Vomiting
Acidosis (build-up of carbon dioxide in the blood)
Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Chills (felling of cold)
Depression
Dysphonia (speech disorder attributable to a disorder of phonation)
Ear pruritus (pruritus or itching is ""the unpleasant skin sensation that frequently provokes scratching"" in ear)
Haemorrhage (bleeding)
Hemiparesis (weakness on one side of the body)

What are the existing conditions these people have? *

Constipation: 11 people, 34.38%
Pneumonia: 10 people, 31.25%
High Blood Cholesterol: 10 people, 31.25%
Cardiac Failure: 10 people, 31.25%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 10 people, 31.25%
Alcohol Withdrawal Syndrome: 10 people, 31.25%
Acute Kidney Failure: 10 people, 31.25%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 12.50%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 4 people, 12.50%
Osteoporosis (bones weak and more likely to break): 2 people, 6.25%

* Approximation only. Some reports may have incomplete information.

Do you take Acetaminophen and codeine phosphate and Codeine?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously