Acetaminophen and Synjardy drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Acetaminophen (acetaminophen) and Synjardy (empagliflozin; metformin hydrochloride). Common drug interactions include initial insomnia among females and cholelithiasis obstructive among males.

The phase IV clinical study analyzes what interactions people have when they take Acetaminophen and Synjardy. It is created by eHealthMe based on reports of 53 people who take the same drugs from the FDA, and is updated regularly.

What is Acetaminophen?

Acetaminophen has active ingredients of acetaminophen. It is often used in pain. eHealthMe is studying from 183,077 Acetaminophen users. Check the latest studies of Acetaminophen.

What is Synjardy?

Synjardy has active ingredients of empagliflozin; metformin hydrochloride. eHealthMe is studying from 2,928 Synjardy users. Check the latest studies of Synjardy.

On Jul, 20, 2026

53 people who take Acetaminophen and Synjardy together, and have interactions are studied.

Acetaminophen and Synjardy drug interactions.

What are the common drug interactions of Acetaminophen and Synjardy, by gender? *:

female:

Initial insomnia (feeling of inadequate or poor-quality sleep)
Injection site pain
Insomnia (sleeplessness)
Joint injury
Joint swelling
Ligament sprain (ligament stretched)
Limb injury
Loss of consciousness
Muscle injury
Muscle strain (an injury to a muscle in which the muscle fibres tear)

male:

Cholelithiasis obstructive (gall stone obstructs bile ducts)
Discomfort
Bone pain
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cardiac failure
Constipation
Fungal infection
Hydronephrosis (water inside the kidney)
Hypogammaglobulinaemia (an abnormally low concentration of gamma globulin in the blood and increased risk of infection)
Infection

What are the common drug interactions of Acetaminophen and Synjardy, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Discomfort
Peripheral swelling
Poor venous access
Weight increased
Back pain
Cardiac failure

50-59:

Infusion related reaction
Pyrexia (fever)
Abdominal discomfort
Chest pain
Constipation
Nausea (feeling of having an urge to vomit)
Pleural effusion (water on the lungs)
Skin discolouration (change of skin colour)

60+:

Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cholelithiasis obstructive (gall stone obstructs bile ducts)
Blood glucose decreased
Blood immunoglobulin g decreased
Bone pain
Breast cyst
Cardiac failure
Cellulitis (infection under the skin)
Constipation
Cough

What are the existing conditions these people have? *

Primary Amyloidosis (disease that occurs when substances called amyloid proteins build up in your organs): 23 people, 43.40%
Ankylosing Spondylitis (type of arthritis affecting the spine): 6 people, 11.32%
Amyloidosis (a tumour within which amyloid is produced): 6 people, 11.32%
Type 2 Diabetes: 3 people, 5.66%
Diabetes: 3 people, 5.66%

* Approximation only. Some reports may have incomplete information.

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