Adderall 10 and Benadryl drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Adderall 10 (amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate) and Benadryl (diphenhydramine hydrochloride). Common drug interactions include atelectasis among females and aggression among males.

The phase IV clinical study analyzes what interactions people have when they take Adderall 10 and Benadryl. It is created by eHealthMe based on reports of 48 people who take the same drugs from the FDA, and is updated regularly.

What is Adderall 10?

Adderall 10 has active ingredients of amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 5,182 Adderall 10 users. Check the latest studies of Adderall 10.

What is Benadryl?

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. eHealthMe is studying from 104,954 Benadryl users. Check the latest studies of Benadryl.

On Jul, 11, 2026

48 people who take Adderall 10 and Benadryl together, and have interactions are studied.

Adderall 10 and Benadryl drug interactions.

What are the common drug interactions of Adderall 10 and Benadryl, by gender? *:

female:

Atelectasis (partial or complete collapse of the lung)
Bronchopleural fistula
Cerebrovascular disorder (disease of brain)
Cervical spinal stenosis (narrowing of the spinal canal in the neck)
Chondromalacia (anterior knee pain due to irritation of the cartilage on the under surface of the kneecap)
Cyst (a closed sac)
Dyspnoea (difficult or laboured respiration)
Dyspnoea exertional (breathlessness or shortness of breath)
Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs)
Empyema (collection of pus in a cavity in the body)

male:

Aggression
Agitation (state of anxiety or nervous excitement)
Memory impairment
Mood swings (an extreme or rapid change in mood)
Weight increased
Anticonvulsant drug level below therapeutic
Autism (a mental condition, present from early childhood, characterized by difficulty in communicating and forming relationships with other people and in using language and abstract concepts)
Bipolar disorder (mood disorder)
Blood thyroid stimulating hormone decreased
Cardiovascular disorder (heart diseases)

What are the common drug interactions of Adderall 10 and Benadryl, by age (0-1 to 60+)? *:

0-1:

Aggression
Agitation (state of anxiety or nervous excitement)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Foaming at mouth (excess saliva secretion)
Tardive dyskinesia (a disorder that involves involuntary movements)

2-9:

Aggression
Agitation (state of anxiety or nervous excitement)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Dyspnoea (difficult or laboured respiration)
Hallucination, visual (seeing things that aren't there)
Heart rate increased
Hypoaesthesia (reduced sense of touch or sensation)
Irritability

10-19:

Aggression
Agitation (state of anxiety or nervous excitement)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Extrapyramidal disorder (involuntary muscle spasms in the face and neck)
Foaming at mouth (excess saliva secretion)
Tardive dyskinesia (a disorder that involves involuntary movements)
Anticonvulsant drug level below therapeutic
Autism (a mental condition, present from early childhood, characterized by difficulty in communicating and forming relationships with other people and in using language and abstract concepts)
Bipolar disorder (mood disorder)
Blood thyroid stimulating hormone decreased

20-29:

Alopecia (absence of hair from areas of the body)
Anxiety
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Epistaxis (bleed from the nose)
Headache (pain in head)
Hypoaesthesia (reduced sense of touch or sensation)
Joint crepitation
Pulmonary embolism (blockage of the main artery of the lung)
Raynaud's phenomenon (discoloration of the fingers, toes, and occasionally other areas)
Skin discolouration (change of skin colour)

30-39:

Anaemia (lack of blood)
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Dyspnoea (difficult or laboured respiration)
Haematochezia (passage of stools containing blood)
Hypokalaemia (low potassium)
Upper respiratory tract infection
Vomiting
Abdominal distension
Chest pain
Cough

40-49:

Weight increased
Abdominal distension
Acute sinusitis
Anxiety
Arthralgia (joint pain)
Atrophy (wasting away of a part of the body)
Blood glucose increased
Breast cancer
Breast cancer in situ
Breast cyst

50-59:

Nausea (feeling of having an urge to vomit)
Abscess (pus)
Chondromalacia (anterior knee pain due to irritation of the cartilage on the under surface of the kneecap)
Cough
Cyst (a closed sac)
Diarrhoea
Dyspnoea exertional (breathlessness or shortness of breath)
Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs)
Empyema (collection of pus in a cavity in the body)
Eye discharge

60+:

n/a

What are the existing conditions these people have? *

Bone Density Abnormal: 6 people, 12.50%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 4 people, 8.33%
Allergic Rhinitis: 4 people, 8.33%
Hypersensitivity: 3 people, 6.25%
Bipolar Disorder (mood disorder): 3 people, 6.25%

* Approximation only. Some reports may have incomplete information.

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