Ambien cr and Actos drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ambien cr (zolpidem tartrate) and Actos (pioglitazone hydrochloride). Common drug interactions include gastrooesophageal reflux disease among females and abdominal pain among males.

The phase IV clinical study analyzes what interactions people have when they take Ambien cr and Actos. It is created by eHealthMe based on reports of 59 people who take the same drugs from the FDA, and is updated regularly.

What is Ambien cr?

Ambien cr has active ingredients of zolpidem tartrate. It is often used in insomnia. eHealthMe is studying from 5,660 Ambien cr users. Check the latest studies of Ambien cr.

What is Actos?

Actos has active ingredients of pioglitazone hydrochloride. It is often used in diabetes. eHealthMe is studying from 49,754 Actos users. Check the latest studies of Actos.

On Jul, 13, 2026

59 people who take Ambien cr and Actos together, and have interactions are studied.

What are the common drug interactions of Ambien Cr and Actos, by gender? *:

female:

Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hypotension (abnormally low blood pressure)
Impaired gastric emptying
Muscle twitching
Panic attack
Sinusitis (inflammation of sinus)
Diarrhoea
Fall
Weight increased
Abdominal pain

male:

Abdominal pain
Anxiety
Gingival pain (gum pain)
Nausea (feeling of having an urge to vomit)
Nephrolithiasis (calculi in the kidneys)
Pancreatitis (inflammation of pancreas)
Tooth abscess (pus formation in tooth)
Tooth fracture
Tooth loss
Wheezing (a high-pitched whistling sound made while you breath)

What are the common drug interactions of Ambien Cr and Actos, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Abdominal pain
Bile duct obstruction (blockage in the tubes that carry bile from the liver to the gallbladder)
Diarrhoea
Headache (pain in head)
Pancreatitis (inflammation of pancreas)
Renal injury (kidney injury)
Constipation
Drug screen positive
Nausea (feeling of having an urge to vomit)

40-49:

Weight increased
Asthenia (weakness)
Back disorder
Back pain
Blood cholesterol increased
Blood triglycerides increased
Dyspnoea (difficult or laboured respiration)
Glucose tolerance impaired (blood glucose is raised beyond normal levels, but not high enough to warrant a diabetes diagnosis)
Hypertension (high blood pressure)
Mixed hyperlipidaemia (elevated concentrations of any or all of the lipids in the plasma)

50-59:

Tooth abscess (pus formation in tooth)
Tooth fracture
Tooth loss
Wheezing (a high-pitched whistling sound made while you breath)
Abdominal pain
Blood creatinine increased
Blood urea increased
Chills (felling of cold)
Dehydration (dryness resulting from the removal of water)
Drug ineffective

60+:

Abdominal pain
Fall
Dyspnoea (difficult or laboured respiration)
Epistaxis (bleed from the nose)
Haematuria (presence of blood in urine)
Hyperhidrosis (abnormally increased sweating)
Hypertension (high blood pressure)
Nervousness
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
Prostatic obstruction (urinary flow along the urinary tract is impaired by prostate enlargement)

What are the existing conditions these people have? *

Type 2 Diabetes: 13 people, 22.03%
Sleep Disorder: 10 people, 16.95%
Pain: 10 people, 16.95%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 9 people, 15.25%
High Blood Pressure: 8 people, 13.56%
High Blood Cholesterol: 6 people, 10.17%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 8.47%
Depression: 5 people, 8.47%
Hypertonic Bladder (bladder-storage function that causes a sudden urge to urinate): 4 people, 6.78%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 4 people, 6.78%

* Approximation only. Some reports may have incomplete information.

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