Cafergot and Ibuprofen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cafergot (caffeine; ergotamine tartrate) and Ibuprofen (ibuprofen). Common drug interactions include bronchitis among females and depression among males.

The phase IV clinical study analyzes what interactions people have when they take Cafergot and Ibuprofen. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.

What is Cafergot?

Cafergot has active ingredients of caffeine; ergotamine tartrate. It is often used in migraine. eHealthMe is studying from 531 Cafergot users. Check the latest studies of Cafergot.

What is Ibuprofen?

Ibuprofen has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 245,270 Ibuprofen users. Check the latest studies of Ibuprofen.

On Jul, 27, 2026

20 people who take Cafergot and Ibuprofen together, and have interactions are studied.

Cafergot and Ibuprofen drug interactions.

What are the common drug interactions of Cafergot and Ibuprofen, by gender? *:

female:

Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Cholecystitis chronic (long lasting infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Cluster headache (one-sided head pain with tearing)
Colitis (inflammation of colon)
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)
Exostosis (formation of new bone on the surface of a bone)
Fall
Femur fracture

male:

Depression
Emotional distress
Hypersexuality
Obsessive-compulsive personality disorder (a mental health condition in which a person is preoccupied with rules, orderliness, and control)
Pathological gambling
Suicidal ideation
Blindness transient (sudden loss of vision)

What are the common drug interactions of Cafergot and Ibuprofen, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Angina pectoris (chest pain due to ischemia of the heart muscle)
Anxiety
Asthma
Dyspnoea (difficult or laboured respiration)
Palpitations (feelings or sensations that your heart is pounding or racing)
Sweating increased (excess sweating)
Blindness transient (sudden loss of vision)
Cardiovascular disorder (heart diseases)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Costochondritis (chest wall pain)

30-39:

n/a

40-49:

Accommodation disorder
Coordination abnormal (abnormal movement)
Vision blurred

50-59:

Bone metabolism disorder
Breast disorder
Fall
Femur fracture
Gastric polyps (abnormal growth of stomach tissue projecting from a mucous membrane)
Gastritis (inflammation of stomach)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Gingival disorder (gum disease)
Haemorrhagic anaemia (anaemia due to excessive bleeding)
Haemorrhoids (a swollen vein or group of veins in the region of the anus)

60+:

n/a

What are the existing conditions these people have? *

Headache (pain in head): 11 people, 55.00%
Hypersensitivity: 8 people, 40.00%
Osteoporosis (bones weak and more likely to break): 7 people, 35.00%
Osteopenia (a condition where bone mineral density is lower than normal): 7 people, 35.00%
Breast Cancer: 7 people, 35.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 25.00%
Depression: 5 people, 25.00%
High Blood Cholesterol: 5 people, 25.00%
Diabetes: 4 people, 20.00%
Restless Leg Syndrome (a powerful urge to move your legs): 4 people, 20.00%

* Approximation only. Some reports may have incomplete information.

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