Comtan and Flonase drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Comtan (entacapone) and Flonase (fluticasone propionate). Common drug interactions include cough among females and fall among males.

The phase IV clinical study analyzes what interactions people have when they take Comtan and Flonase. It is created by eHealthMe based on reports of 30 people who take the same drugs from the FDA, and is updated regularly.

What is Comtan?

Comtan has active ingredients of entacapone. It is often used in parkinson's disease. eHealthMe is studying from 3,979 Comtan users. Check the latest studies of Comtan.

What is Flonase?

Flonase has active ingredients of fluticasone propionate. It is often used in allergies. eHealthMe is studying from 75,441 Flonase users. Check the latest studies of Flonase.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 21, 2026

30 people who take Comtan and Flonase together, and have interactions are studied.

What are the common drug interactions of Comtan and Flonase, by gender? *:

female:

Cough
Tooth discolouration (a change in colour of teeth)
Tooth fracture
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Anxiety
Depression
Dyskinesia (abnormality or impairment of voluntary movement)
Pathological gambling
Altered state of consciousness (altered state of mind)
Encephalitis (inflammation of the brain)

male:

Fall
Death
Drug ineffective
Hallucination, visual (seeing things that aren't there)
Hypotension (abnormally low blood pressure)
Weight decreased
Agitation (state of anxiety or nervous excitement)
Compulsive sexual behaviour (unable to manage his/her sexual behaviour)
Confusional state
Delusional disorder, unspecified type

What are the common drug interactions of Comtan and Flonase, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Balance disorder
Gait disturbance

60+:

Dyskinesia (abnormality or impairment of voluntary movement)
Fall
Dizziness
Balance disorder
Drug ineffective
Hallucination, visual (seeing things that aren't there)
Hypotension (abnormally low blood pressure)
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Weight decreased
Agitation (state of anxiety or nervous excitement)

What are the existing conditions these people have? *

On And Off Phenomenon: 5 people, 16.67%
Pain: 3 people, 10.00%
Oedema Peripheral (superficial swelling): 3 people, 10.00%
Movement - Uncontrolled Or Slow: 3 people, 10.00%
Orthostatic Hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up): 2 people, 6.67%
Muscle Rigidity (muscle stiffness): 2 people, 6.67%
Dyskinesia (abnormality or impairment of voluntary movement): 2 people, 6.67%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 2 people, 6.67%

* Approximation only. Some reports may have incomplete information.

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