Estrace and Metformin hydrochloride drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Estrace (estradiol) and Metformin hydrochloride (metformin hydrochloride). Common drug interactions include pain in extremity among females and gait disturbance among males.

The phase IV clinical study analyzes what interactions people have when they take Estrace and Metformin hydrochloride. It is created by eHealthMe based on reports of 56 people who take the same drugs from the FDA, and is updated regularly.

What is Estrace?

Estrace has active ingredients of estradiol. It is often used in hormone replacement therapy. eHealthMe is studying from 16,703 Estrace users. Check the latest studies of Estrace.

What is Metformin hydrochloride?

Metformin hydrochloride has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 58,646 Metformin hydrochloride users. Check the latest studies of Metformin hydrochloride.

On Jul, 17, 2026

56 people who take Estrace and Metformin hydrochloride together, and have interactions are studied.

Estrace and Metformin hydrochloride drug interactions.

What are the common drug interactions of Estrace and Metformin Hydrochloride, by gender? *:

female:

Pain in extremity
Cough
Fibrosis (formation of excess fibrous connective tissue in an organ or tissue)
Nausea (feeling of having an urge to vomit)
Vomiting
Decreased appetite
Myalgia (muscle pain)
Oral infection
Urinary tract infection
Cellulitis (infection under the skin)

male:

Gait disturbance
Hypertension (high blood pressure)
Sleep-related eating disorder (abnormal eating patterns during the night)
Somnambulism (sleep walking)
Tremor (trembling or shaking movements in one or more parts of your body)

What are the common drug interactions of Estrace and Metformin Hydrochloride, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Hypertension (high blood pressure)
Sleep-related eating disorder (abnormal eating patterns during the night)
Somnambulism (sleep walking)

40-49:

Fibrosis (formation of excess fibrous connective tissue in an organ or tissue)
Myalgia (muscle pain)
Oral infection
Cough
Headache (pain in head)
Malaise (a feeling of general discomfort or uneasiness)
Nasopharyngitis (inflammation of the nasopharynx)

50-59:

Sensory loss (senses loss)
Vulvovaginal disorder
Yawning (simultaneous inhalation of air and stretching of the eardrums, followed by exhalation of breath)
Angioedema (rapid swelling of the dermis)
Application site burn
Breast tenderness
Fatigue (feeling of tiredness)
Nausea (feeling of having an urge to vomit)
Sensation of heaviness

60+:

Pain
Diarrhoea
Road traffic accident
Vomiting
Abdominal pain
Bone pain
Breast cancer
Cough
Decreased appetite
Dizziness

What are the existing conditions these people have? *

Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 12 people, 21.43%
Arrhythmias (irregular heartbeat): 10 people, 17.86%
Immunodeficiency Common Variable: 6 people, 10.71%
Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 6 people, 10.71%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 4 people, 7.14%
Muscle Spasms (muscle contraction): 4 people, 7.14%
High Blood Cholesterol: 4 people, 7.14%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 7.14%
Type 2 Diabetes: 3 people, 5.36%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 5.36%

* Approximation only. Some reports may have incomplete information.

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