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Gazyva and Metformin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Gazyva (obinutuzumab) and Metformin (metformin hydrochloride). Common drug interactions include anxiety among females and fatigue among males.

The phase IV clinical study analyzes what interactions people have when they take Gazyva and Metformin. It is created by eHealthMe based on reports of 59 people who take the same drugs from the FDA, and is updated regularly.

What is Gazyva?

Gazyva has active ingredients of obinutuzumab. eHealthMe is studying from 4,470 Gazyva users. Check the latest studies of Gazyva.

What is Metformin?

Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 465,354 Metformin users. Check the latest studies of Metformin.

On Jul, 12, 2026

59 people who take Gazyva and Metformin together, and have interactions are studied.

Gazyva and Metformin drug interactions.

What are the common drug interactions of Gazyva and Metformin, by gender? *:

female:

  1. Anxiety
  2. Asthenia (weakness)
  3. Bradycardia (abnormally slow heart action)
  4. Depressed mood
  5. Diarrhoea
  6. Discomfort
  7. Dizziness
  8. Gastrointestinal disorder (functional problems of gastrointestinal tract)
  9. Hypotension (abnormally low blood pressure)
  10. Influenza

male:

  1. Fatigue (feeling of tiredness)
  2. Death
  3. Thrombocytopenia (decrease of platelets in blood)
  4. Abdominal pain
  5. Constipation
  6. Cough
  7. Fluid retention (an abnormal accumulation of fluid in the blood)
  8. Infection
  9. Nausea (feeling of having an urge to vomit)
  10. Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)

What are the common drug interactions of Gazyva and Metformin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

  1. Fatigue (feeling of tiredness)
  2. Respiratory failure (inadequate gas exchange by the respiratory system)
  3. White blood cell count decreased
  4. Chest discomfort
  5. Somnolence (a state of near-sleep, a strong desire for sleep)
  6. Cytomegalovirus chorioretinitis (infection of choroid and retina of the eye from virus)
  7. Asthenia (weakness)
  8. Chest pain
  9. Death
  10. Weight increased

What are the existing conditions these people have? *

  1. Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 27 people, 45.76%
  2. Burkitt Lymphoma (cancer of the lymphatic system): 6 people, 10.17%
  3. Leukaemia (blood or bone marrow cancer): 4 people, 6.78%
  4. Nausea (feeling of having an urge to vomit): 3 people, 5.08%
  5. Mantle Cell Lymphoma (cancer of lymphocytes, a type of white blood cell): 3 people, 5.08%

* Approximation only. Some reports may have incomplete information.

Do you take Gazyva and Metformin?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Gazyva and Metformin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Gazyva:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Metformin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Gazyva and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Metformin and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on obinutuzumab and metformin hydrochloride (the active ingredients of Gazyva and Metformin, respectively), and Gazyva and Metformin (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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