Ibuprofen and Alimta drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ibuprofen (ibuprofen) and Alimta (pemetrexed disodium). Common drug interactions include lethargy among females and obstruction among males.

The phase IV clinical study analyzes what interactions people have when they take Ibuprofen and Alimta. It is created by eHealthMe based on reports of 57 people who take the same drugs from the FDA, and is updated regularly.

What is Ibuprofen?

Ibuprofen has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 245,270 Ibuprofen users. Check the latest studies of Ibuprofen.

What is Alimta?

Alimta has active ingredients of pemetrexed disodium. eHealthMe is studying from 7,702 Alimta users. Check the latest studies of Alimta.

On Aug, 11, 2026

57 people who take Ibuprofen and Alimta together, and have interactions are studied.

What are the common drug interactions of Ibuprofen and Alimta, by gender? *:

female:

Lethargy (tiredness)
Malaise (a feeling of general discomfort or uneasiness)
Nausea (feeling of having an urge to vomit)
Non-small cell lung cancer metastatic (type of epithelial lung cancer spreads to other parts)
Oral candidiasis (fungal infection of mouth)
Oropharyngeal pain
Tonsillar hypertrophy (enlargement of the tonsils)
Pancreatitis (inflammation of pancreas)
Abdominal pain
Anxiety

male:

Obstruction
Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Malaise (a feeling of general discomfort or uneasiness)
Oesophageal ulcer (ulcer of oesophagus)
Pneumonia
Tremor (trembling or shaking movements in one or more parts of your body)
Vomiting
Abnormal faeces (abnormal stool)
Abnormal weight gain
Adverse event

What are the common drug interactions of Ibuprofen and Alimta, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Obstruction
Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Tumour pain
Malignant neoplasm progression (cancer tumour came back)
Dysphagia (a condition in which swallowing is difficult or painful)
Anaemia (lack of blood)
Arthralgia (joint pain)
Chest pain
Non-small cell lung cancer metastatic (type of epithelial lung cancer spreads to other parts)
Oral candidiasis (fungal infection of mouth)

50-59:

Abdominal pain
Abdominal pain upper
Anxiety
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Cheilitis (infection of lips)
Chest pain
General physical health deterioration (weak health status)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Inappropriate antidiuretic hormone secretion
Inflammatory bowel disease

60+:

Dehydration (dryness resulting from the removal of water)
Malaise (a feeling of general discomfort or uneasiness)
Abnormal weight gain
Adverse event
Aggression
Aortic valve calcification
Cardiac disorder
Clavicle fracture
Colitis (inflammation of colon)
Decreased appetite

What are the existing conditions these people have? *

Lung Cancer - Non-Small Cell (lung cancer): 22 people, 38.60%
Non-Small Cell Lung Cancer Stage Iv: 13 people, 22.81%
Lung Neoplasm Malignant (cancer tumour of lung): 7 people, 12.28%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 4 people, 7.02%
Neoplasm Malignant (cancer tumour): 3 people, 5.26%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 3 people, 5.26%
High Blood Pressure: 3 people, 5.26%
Chest Pain: 3 people, 5.26%
Analgesia: 3 people, 5.26%

* Approximation only. Some reports may have incomplete information.

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