Indocin and Acetaminophen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Indocin (indomethacin) and Acetaminophen (acetaminophen). Common drug interactions include nausea among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Indocin and Acetaminophen. It is created by eHealthMe based on reports of 88 people who take the same drugs from the FDA, and is updated regularly.

What is Indocin?

Indocin has active ingredients of indomethacin. It is often used in gout. eHealthMe is studying from 4,559 Indocin users. Check the latest studies of Indocin.

What is Acetaminophen?

Acetaminophen has active ingredients of acetaminophen. It is often used in pain. eHealthMe is studying from 183,077 Acetaminophen users. Check the latest studies of Acetaminophen.

On Aug, 07, 2026

88 people who take Indocin and Acetaminophen together, and have interactions are studied.

Indocin and Acetaminophen drug interactions.

What are the common drug interactions of Indocin and Acetaminophen, by gender? *:

female:

Nausea (feeling of having an urge to vomit)
Oedema (fluid collection in tissue)
Platelet count increased
Skin reaction
Vomiting
Weight increased
White blood cell count increased
Renal failure (kidney dysfunction)
Abdominal pain
Beta haemolytic streptococcal infection (infection with streptococcus pyogenes, a beta-haemolytic bacterium cause mild to moderately severe respiratory tract, skin, and soft tissue)

male:

Anxiety
Dizziness
Rotator cuff syndrome (a spectrum of conditions affecting the rotator cuff tendons of the shoulder)
Scoliosis (a medical condition in which a person's spine is curved from side to side)
Spinal osteoarthritis (joint cartilage loss in spine)
Diverticulum intestinal (a pouch that is attached to the first part of the small intestine)
Hyperglycaemia (high blood sugar)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Acute myocardial infarction (acute heart attack)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)

What are the common drug interactions of Indocin and Acetaminophen, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Dysgeusia (disorder of the sense of taste)
Parosmia (distortion of the sense of smell, as in smelling odours that are not present)

30-39:

Pleural effusion (water on the lungs)
Oedema lower limb (fluid collection in tissue of lower leg)
Pneumonia
Cardiomegaly (increased size of heart than normal)
Dyspnoea (difficult or laboured respiration)
Hypotension (abnormally low blood pressure)
Aortic atherosclerosis (degenerative process of aortic arteries)
Atelectasis (partial or complete collapse of the lung)
Blood sodium decreased
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)

40-49:

Injury
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Depression
Disability
Fear
Multi-organ failure (multisystem organ failure)
Renal failure (kidney dysfunction)
Renal infarct (kidney damage due to lack of blood supply)
Renal injury (kidney injury)

50-59:

Bursitis infective staphylococcal (staphylococcal infection of the subacromial/subdeltoid bursa)
Cellulitis (infection under the skin)
Chronic kidney disease
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Dizziness
Face oedema (swelling of face)
Fall
Gammopathy (abnormal proliferation of the lymphoid cells producing immunoglobulins)
Hyperproteinaemia (a metabolic disorder characterized by enhanced plasma proline concentrations and urinary excretion)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)

60+:

Anxiety
Dyspnoea (difficult or laboured respiration)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Renal failure acute (rapid kidney dysfunction)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Coronary artery bypass
Gastric ulcer (stomach ulcer)
Hypotension (abnormally low blood pressure)
Injury
Nephrolithiasis (calculi in the kidneys)

What are the existing conditions these people have? *

High Blood Pressure: 14 people, 15.91%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 13 people, 14.77%
Infection: 11 people, 12.50%
Depression: 8 people, 9.09%
Inflammation: 7 people, 7.95%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 6 people, 6.82%
Hyperlipidaemia (presence of excess lipids in the blood): 6 people, 6.82%
Juvenile Arthritis (arthritis-related condition that develops in children or teenagers): 5 people, 5.68%
High Blood Cholesterol: 5 people, 5.68%
Asthma: 5 people, 5.68%

* Approximation only. Some reports may have incomplete information.

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