Indomethacin and Ampyra drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Indomethacin (indomethacin) and Ampyra (dalfampridine). Common drug interactions include hearing impaired among females and fall among males.

The phase IV clinical study analyzes what interactions people have when they take Indomethacin and Ampyra. It is created by eHealthMe based on reports of 66 people who take the same drugs from the FDA, and is updated regularly.

What is Indomethacin?

Indomethacin has active ingredients of indomethacin. It is often used in gout. eHealthMe is studying from 16,884 Indomethacin users. Check the latest studies of Indomethacin.

What is Ampyra?

Ampyra has active ingredients of dalfampridine. It is often used in multiple sclerosis. eHealthMe is studying from 77,145 Ampyra users. Check the latest studies of Ampyra.



On Jul, 12, 2026

66 people who take Indomethacin and Ampyra together, and have interactions are studied.

Indomethacin and Ampyra drug interactions.

What are the common drug interactions of Indomethacin and Ampyra, by gender? *:

female:

  1. Hearing impaired
  2. Herpes zoster
  3. Hot flush (sudden feelings of heat)
  4. Hypoaesthesia oral (reduced sense of touch or sensation in mouth)
  5. Immunosuppression
  6. Insomnia (sleeplessness)
  7. Intervertebral disc disorder (spinal disc disorder)
  8. Intervertebral disc protrusion (spinal disc protrusion)
  9. Loss of consciousness
  10. Lymphocyte count decreased

male:

  1. Fall
  2. Gait disturbance
  3. Fear
  4. Muscle fatigue (a condition in which muscles cannot exert their normal force)
  5. Rash
  6. Mobility decreased (ability to move is reduced)
  7. Muscular weakness (muscle weakness)
  8. Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
  9. Confusional state
  10. Disorientation (disability in which the senses of time, direction, and recognition of people and places)

What are the common drug interactions of Indomethacin and Ampyra, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

  1. Gait disturbance
  2. Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
  3. Nephrolithiasis (calculi in the kidneys)
  4. Pneumonia staphylococcal (pneumonia staphylococcal infections are usually caused by the organism staphylococcus aureus)
  5. Wisdom teeth removal
  6. Disturbance in attention
  7. Disturbance in social behaviour
  8. Drug ineffective

10-19:

n/a

20-29:

n/a

30-39:

  1. Cheilitis (infection of lips)
  2. Hypersensitivity
  3. Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
  4. Stomatitis (inflammation of mucous membrane of mouth)
  5. Ankle fracture
  6. Back pain
  7. Fall
  8. Gait disturbance
  9. Intervertebral disc protrusion (spinal disc protrusion)
  10. Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)

40-49:

  1. Rash papular (redness with papule)
  2. Spinal osteoarthritis (joint cartilage loss in spine)
  3. Suicidal ideation
  4. Uhthoff's phenomenon (heat intolerance)
  5. Urge incontinence (urinary incontinence)
  6. Fatigue (feeling of tiredness)
  7. Flushing (the warm, red condition of human skin)
  8. Sinusitis (inflammation of sinus)
  9. Balance disorder
  10. Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)

50-59:

  1. Fall
  2. Gait disturbance
  3. Drug ineffective
  4. Fatigue (feeling of tiredness)
  5. Asthenia (weakness)
  6. Mobility decreased (ability to move is reduced)
  7. Constipation
  8. Fear
  9. Muscle fatigue (a condition in which muscles cannot exert their normal force)
  10. Rash

60+:

  1. Fall
  2. Memory impairment
  3. Sleep disorder
  4. Diarrhoea
  5. Drug hypersensitivity
  6. Extranodal marginal zone b-cell lymphoma (malt type) (cancer originating from b cells in the marginal zone of the malt)
  7. Gastrointestinal disorder (functional problems of gastrointestinal tract)
  8. Hearing impaired
  9. Insomnia (sleeplessness)
  10. Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)

What are the existing conditions these people have? *

  1. Gait Disturbance: 19 people, 28.79%

* Approximation only. Some reports may have incomplete information.

Do you take Indomethacin and Ampyra?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Indomethacin and Ampyra:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Indomethacin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Ampyra:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Indomethacin and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Ampyra and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on indomethacin and dalfampridine (the active ingredients of Indomethacin and Ampyra, respectively), and Indomethacin and Ampyra (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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