Isoniazid and Thalidomide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Isoniazid (isoniazid) and Thalidomide (thalidomide). Common drug interactions include drug ineffective among females and drug ineffective among males.

The phase IV clinical study analyzes what interactions people have when they take Isoniazid and Thalidomide. It is created by eHealthMe based on reports of 49 people who take the same drugs from the FDA, and is updated regularly.

What is Isoniazid?

Isoniazid has active ingredients of isoniazid. It is often used in tuberculosis. eHealthMe is studying from 20,174 Isoniazid users. Check the latest studies of Isoniazid.

What is Thalidomide?

Thalidomide has active ingredients of thalidomide. eHealthMe is studying from 16,473 Thalidomide users. Check the latest studies of Thalidomide.



On Jul, 26, 2026

49 people who take Isoniazid and Thalidomide together, and have interactions are studied.

Isoniazid and Thalidomide drug interactions.

What are the common drug interactions of Isoniazid and Thalidomide, by gender? *:

female:

  1. Drug ineffective
  2. Bradycardia (abnormally slow heart action)
  3. Hepatitis (inflammation of the liver)
  4. Arterial occlusive disease (slow process through which arteries throughout the body become progressively narrowed and eventually completely blocked)
  5. Arteritis (inflammation of the walls of arteries)
  6. Carotid artery stenosis (narrowing of carotid artery)
  7. Hemiparesis (weakness on one side of the body)
  8. Interstitial lung disease
  9. Tuberculosis of central nervous system (a bacterial infection of brain and spinal cord by mycobacterium tuberculosis)
  10. Vasculitis (inflammation of a blood vessel or blood vessels)

male:

  1. Drug ineffective
  2. Drug resistance (reduction in effectiveness of a drug)
  3. Retroperitoneal haemorrhage (bleeding between the peritoneum and the posterior abdominal wall)
  4. Neuropathy peripheral (surface nerve damage)
  5. Blood uric acid increased
  6. Disseminated tuberculosis
  7. Plasma cell myeloma (cancer that begins in plasma cells)
  8. Death
  9. Ischaemia (insufficient supply of blood to an organ, usually due to a blocked artery)
  10. Therapeutic response unexpected

What are the common drug interactions of Isoniazid and Thalidomide, by age (0-1 to 60+)? *:

0-1:

  1. Cerebral infarction (less blood supply to brain resulting tissue damage)

2-9:

  1. Arterial occlusive disease (slow process through which arteries throughout the body become progressively narrowed and eventually completely blocked)
  2. Arteritis (inflammation of the walls of arteries)
  3. Carotid artery stenosis (narrowing of carotid artery)
  4. Hemiparesis (weakness on one side of the body)
  5. Cerebral ischaemia (insufficient blood flow to the brain to meet metabolic demand)
  6. Thalamic infarction (tissue death of thalamus part of brain)

10-19:

n/a

20-29:

n/a

30-39:

  1. Drug resistance (reduction in effectiveness of a drug)
  2. Somnolence (a state of near-sleep, a strong desire for sleep)
  3. Drug ineffective
  4. Brain oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain)
  5. Hydrocephalus (water on the brain)
  6. Thalamic infarction (tissue death of thalamus part of brain)
  7. Vasculitis (inflammation of a blood vessel or blood vessels)
  8. Cardiac arrest
  9. Tuberculosis of central nervous system (a bacterial infection of brain and spinal cord by mycobacterium tuberculosis)
  10. Blood uric acid increased

40-49:

  1. Drug ineffective
  2. Bradycardia (abnormally slow heart action)
  3. Hepatitis (inflammation of the liver)
  4. Tuberculosis of central nervous system (a bacterial infection of brain and spinal cord by mycobacterium tuberculosis)
  5. Vasculitis (inflammation of a blood vessel or blood vessels)
  6. Paradoxical drug reaction
  7. Transaminases increased
  8. Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
  9. Cushingoid (obesity and weakening of the muscles)
  10. Depressed mood

50-59:

  1. Drug ineffective

60+:

  1. Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
  2. Retroperitoneal haemorrhage (bleeding between the peritoneum and the posterior abdominal wall)
  3. Tuberculosis gastrointestinal (a bacterial infection of digestive tract by mycobacterium tuberculosis)
  4. Drug ineffective
  5. Interstitial lung disease
  6. Disseminated tuberculosis
  7. Plasma cell myeloma (cancer that begins in plasma cells)
  8. Stress cardiomyopathy (stress-induced chronic disease of the heart muscle)
  9. Anal abscess
  10. Pneumonia

What are the existing conditions these people have? *

  1. Tuberculosis Of Central Nervous System (a bacterial infection of brain and spinal cord by mycobacterium tuberculosis): 23 people, 46.94%
  2. Disseminated Tuberculosis: 20 people, 40.82%
  3. Multiple Myeloma (cancer of the plasma cells): 11 people, 22.45%
  4. Meningitis Tuberculous (a bacterial infection of the membranes covering the brain and spinal cord (meninges)): 7 people, 14.29%

* Approximation only. Some reports may have incomplete information.

Do you take Isoniazid and Thalidomide?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Isoniazid and Thalidomide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Isoniazid:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Thalidomide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Isoniazid and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Thalidomide and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on isoniazid and thalidomide (the active ingredients of Isoniazid and Thalidomide, respectively), and Isoniazid and Thalidomide (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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