Lonsurf and Acetaminophen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lonsurf (tipiracil hydrochloride; trifluridine) and Acetaminophen (acetaminophen). Common drug interactions include fatigue among females and death among males.

The phase IV clinical study analyzes what interactions people have when they take Lonsurf and Acetaminophen. It is created by eHealthMe based on reports of 62 people who take the same drugs from the FDA, and is updated regularly.

What is Lonsurf?

Lonsurf has active ingredients of tipiracil hydrochloride; trifluridine. eHealthMe is studying from 10,077 Lonsurf users. Check the latest studies of Lonsurf.

What is Acetaminophen?

Acetaminophen has active ingredients of acetaminophen. It is often used in pain. eHealthMe is studying from 183,077 Acetaminophen users. Check the latest studies of Acetaminophen.

On Jul, 07, 2026

62 people who take Lonsurf and Acetaminophen together, and have interactions are studied.

Lonsurf and Acetaminophen drug interactions.

What are the common drug interactions of Lonsurf and Acetaminophen, by gender? *:

female:

Fatigue (feeling of tiredness)
Decreased appetite
Diarrhoea
Death
Dehydration (dryness resulting from the removal of water)
Constipation
Disease progression
Nausea (feeling of having an urge to vomit)
Stomatitis (inflammation of mucous membrane of mouth)
Abdominal pain

male:

Death
Disease progression
Dyspnoea (difficult or laboured respiration)
Ageusia (loss of taste functions of the tongue)
Anaemia (lack of blood)
Dehydration (dryness resulting from the removal of water)
Diabetes mellitus inadequate control
Iron deficiency
Leukopenia (less number of white blood cells in blood)
Nephrolithiasis (calculi in the kidneys)

What are the common drug interactions of Lonsurf and Acetaminophen, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Abdominal pain
Anxiety
Blood bilirubin increased
Colorectal cancer metastatic (cancer of colon and rectal spreads to other parts)
Death
Decreased appetite
Disease progression
Dyspnoea (difficult or laboured respiration)
Dysuria (painful or difficult urination)
Fatigue (feeling of tiredness)

50-59:

Fatigue (feeling of tiredness)
Decreased appetite
Dehydration (dryness resulting from the removal of water)
Diarrhoea
Febrile neutropenia (fever with reduced white blood cells)
Stomatitis (inflammation of mucous membrane of mouth)
Weight decreased
Death
Apnoea (suspension of external breathing)
Constipation

60+:

Fatigue (feeling of tiredness)
Death
Dizziness
Neutropenia (an abnormally low number of neutrophils)
White blood cell count decreased
Abdominal pain upper
Ageusia (loss of taste functions of the tongue)
Anaemia (lack of blood)
Dehydration (dryness resulting from the removal of water)
Diabetes mellitus inadequate control

What are the existing conditions these people have? *

Colon Cancer: 30 people, 48.39%
Rectal Cancer (cancer of rectum): 15 people, 24.19%
Colorectal Cancer Metastatic (cancer of colon and rectal spreads to other parts): 5 people, 8.06%

* Approximation only. Some reports may have incomplete information.

Do you take Lonsurf and Acetaminophen?

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