Lorazepam and Nexplanon drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lorazepam (lorazepam) and Nexplanon (etonogestrel). Common drug interactions include implant site pain among females.

The phase IV clinical study analyzes what interactions people have when they take Lorazepam and Nexplanon. It is created by eHealthMe based on reports of 75 people who take the same drugs from the FDA, and is updated regularly.

What is Lorazepam?

Lorazepam has active ingredients of lorazepam. It is often used in stress and anxiety. eHealthMe is studying from 165,639 Lorazepam users. Check the latest studies of Lorazepam.

What is Nexplanon?

Nexplanon has active ingredients of etonogestrel. It is often used in birth control. eHealthMe is studying from 46,431 Nexplanon users. Check the latest studies of Nexplanon.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

75 people who take Lorazepam and Nexplanon together, and have interactions are studied.

Lorazepam and Nexplanon drug interactions.

What are the common drug interactions of Lorazepam and Nexplanon, by gender? *:

female:

Implant site pain
Headache (pain in head)
Hypersensitivity
Lung disorder (lung disease)
Dizziness
Head injury
Somnolence (a state of near-sleep, a strong desire for sleep)
Complication of device insertion
Infusion related reaction
Lower respiratory tract infection

male:

n/a

What are the common drug interactions of Lorazepam and Nexplanon, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Complication of device insertion
Device expulsion
Skin ulcer
Affect lability (emotional incontinence)
Amenorrhoea (absence of a menstrual period in a woman of reproductive age)
Implant site erythema (redness at implant site)
Infective pulmonary exacerbation of cystic fibrosis (severe infective lung disease with production of abnormally thick mucus)
Menorrhagia (an abnormally heavy bleeding and prolonged menstrual period at regular intervals)
Mood altered (changes in mood)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)

20-29:

Haemorrhagic cyst (bleeding cyst)
Infusion site haemorrhage (bleeding from infusion site)
Limb injury
Menorrhagia (an abnormally heavy bleeding and prolonged menstrual period at regular intervals)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Nervousness
Ovarian cyst (fluid filled sac of the ovary)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Suicidal ideation
Tonsillar hypertrophy (enlargement of the tonsils)

30-39:

Coma (state of unconsciousness lasting more than six hours)
Decreased appetite
Fatigue (feeling of tiredness)
Head injury
Hypersomnia (excessive daytime sleepiness (eds))
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Somnolence (a state of near-sleep, a strong desire for sleep)
Syncope (loss of consciousness with an inability to maintain postural tone)
Acne cystic (skin problems that cause pimples)
Burning sensation

40-49:

Infusion related reaction
Lower limb fracture
Lower respiratory tract infection
Meningitis (inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges)
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Pneumonia
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
Sepsis (a severe blood infection that can lead to organ failure and death)
Staphylococcal infection (an infection with staphylococcus bacteria)
Syncope (loss of consciousness with an inability to maintain postural tone)

50-59:

n/a

60+:

Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures)
Hip arthroplasty
Pneumonia
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 8 people, 10.67%
Immunodeficiency Common Variable: 8 people, 10.67%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 7 people, 9.33%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 6 people, 8.00%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 5.33%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 4 people, 5.33%
Myasthenia Gravis (a chronic condition that causes muscles to tire and weaken easily): 4 people, 5.33%
Cystic Fibrosis (disease of the secretary glands): 4 people, 5.33%

* Approximation only. Some reports may have incomplete information.

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