Lorcet-hd and Ibuprofen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lorcet-hd (acetaminophen; hydrocodone bitartrate) and Ibuprofen (ibuprofen). Common drug interactions include skin discolouration among females and depression among males.

The phase IV clinical study analyzes what interactions people have when they take Lorcet-hd and Ibuprofen. It is created by eHealthMe based on reports of 64 people who take the same drugs from the FDA, and is updated regularly.

What is Lorcet-hd?

Lorcet-hd has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. eHealthMe is studying from 2,221 Lorcet-hd users. Check the latest studies of Lorcet-hd.

What is Ibuprofen?

Ibuprofen has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 245,270 Ibuprofen users. Check the latest studies of Ibuprofen.

On Jul, 08, 2026

64 people who take Lorcet-hd and Ibuprofen together, and have interactions are studied.

Lorcet-hd and Ibuprofen drug interactions.

What are the common drug interactions of Lorcet-Hd and Ibuprofen, by gender? *:

female:

Skin discolouration (change of skin colour)
Arrhythmia (irregular heartbeat)
Cardiac disorder
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Diarrhoea
Oedema peripheral (superficial swelling)
Pancreatitis (inflammation of pancreas)
Pancreatitis chronic (chronic inflammation of pancreas)
Anaemia (lack of blood)
Angina unstable (chest pain due to ischemia of the heart muscle- unstable)

male:

Depression
Vomiting
Fatigue (feeling of tiredness)
Impaired healing
Injury
Insomnia (sleeplessness)
Intervertebral disc protrusion (spinal disc protrusion)
Neuropathy peripheral (surface nerve damage)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Pyrexia (fever)

What are the common drug interactions of Lorcet-Hd and Ibuprofen, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Depression
Drug dependence
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Groin infection (infection in groin)
Onychomycosis (fungal infection of the nail)
Suicidal ideation
Tinea cruris (an infection of the groin caused by a fungus)
Diarrhoea
Drug effect decreased
Hypercholesterolaemia (high levels of cholesterol in the blood)

30-39:

Chest pain
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Depression
Vomiting
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Blood cholesterol increased
Cholecystitis infective (infection of gallbladder capable to infect other organs)
Dizziness
Gastrointestinal disorder (functional problems of gastrointestinal tract)

40-49:

Chest pain
Nausea (feeling of having an urge to vomit)
Asthenia (weakness)
Vomiting
Depression
Insomnia (sleeplessness)
Neuropathy peripheral (surface nerve damage)
Fatigue (feeling of tiredness)
Oedema peripheral (superficial swelling)
Skin discolouration (change of skin colour)

50-59:

Pleural effusion (water on the lungs)
Ventricular fibrillation (abnormally irregular heart rhythm)
Abdominal distension
Activities of daily living impaired
Acute prerenal failure (prerenal acute renal failure (arf) occurs when a sudden reduction in blood flow to the kidney)
Acute respiratory failure
Anaemia (lack of blood)
Angina pectoris (chest pain due to ischemia of the heart muscle)
Apnoea (suspension of external breathing)
Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)

60+:

Pain in extremity
Abdominal pain
Hypoaesthesia (reduced sense of touch or sensation)
Muscle spasms (muscle contraction)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Nausea (feeling of having an urge to vomit)
Urinary tract infection
Vomiting
Abdominal pain upper
Alanine aminotransferase increased

What are the existing conditions these people have? *

Stress And Anxiety: 7 people, 10.94%
Headache (pain in head): 7 people, 10.94%
Depression: 7 people, 10.94%
Muscle Spasms (muscle contraction): 6 people, 9.38%
Bipolar Disorder (mood disorder): 6 people, 9.38%
Pain In Extremity: 5 people, 7.81%
Weakness: 4 people, 6.25%
Prostate Cancer: 4 people, 6.25%
Hypoaesthesia (reduced sense of touch or sensation): 4 people, 6.25%

* Approximation only. Some reports may have incomplete information.

Do you take Lorcet-hd and Ibuprofen?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously