Methimazole and Keppra drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Methimazole (methimazole) and Keppra (levetiracetam). Common drug interactions include cerebrovascular accident among females and nausea among males.
The phase IV clinical study analyzes what interactions people have when they take Methimazole and Keppra. It is created by eHealthMe based on reports of 25 people who take the same drugs from the FDA, and is updated regularly.
What is Methimazole?
Methimazole has active ingredients of methimazole. It is often used in hyperthyroidism. eHealthMe is studying from 8,016 Methimazole users. Check the latest studies of Methimazole.
What is Keppra?
Keppra has active ingredients of levetiracetam. It is often used in epilepsy. eHealthMe is studying from 73,504 Keppra users. Check the latest studies of Keppra.
25 people who take Methimazole and Keppra together, and have interactions are studied.

What are the common drug interactions of Methimazole and Keppra, by gender? *:
female:
- Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
- Vision blurred
- Hemiplegia (paralysis of one side of the body)
- Drug ineffective
- Headache (pain in head)
- Pain
- Basedow's disease (autoimmune disease where the thyroid is overactive, producing an excessive amount of thyroid hormones)
- Cataract (clouding of the lens inside the eye)
- Complex partial seizures (epileptic seizure)
- Ear discomfort
male:
- Nausea (feeling of having an urge to vomit)
- Alopecia (absence of hair from areas of the body)
- Death
- Diarrhoea
- Diarrhoea haemorrhagic (bloody diarrhoea)
- Dry skin
- Eructation (release of gas from the digestive tract)
- Feeding disorder (when children refuse to eat certain food groups)
- Flatulence (flatus expelled through the anus)
- Granulocytopenia (lack of granulocyte)
What are the common drug interactions of Methimazole and Keppra, by age (0-1 to 60+)? *:
0-1:
n/a
2-9:
n/a
10-19:
n/a
20-29:
- Cardiac failure congestive
- Haematocrit decreased
- Haemoglobin decreased
- Headache (pain in head)
- Leukopenia (less number of white blood cells in blood)
- Nephrolithiasis (calculi in the kidneys)
- Neutropenia (an abnormally low number of neutrophils)
- Oropharyngeal pain
- Platelet count decreased
- Pneumonia
30-39:
- Drug ineffective
40-49:
- Complex partial seizures (epileptic seizure)
- Drug ineffective
- Ear discomfort
- Eye pain
- Fatigue (feeling of tiredness)
- Headache (pain in head)
- Hyperacusis (disorder in loudness perception)
- Hypertension (high blood pressure)
- Inappropriate affect
- Pain
50-59:
n/a
60+:
- Chronic kidney disease
- Death
- Oedema (fluid collection in tissue)
- Renal failure (kidney dysfunction)
- Urinary tract infection
What are the existing conditions these people have? *
- Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 7 people, 28.00%
- Pain: 4 people, 16.00%
- Seizures (abnormal excessive or synchronous neuronal activity in the brain): 3 people, 12.00%
- Neuralgia (pain in one or more nerves): 3 people, 12.00%
- Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 12.00%
- Insomnia (sleeplessness): 2 people, 8.00%
- Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 8.00%
- Blood Pressure Abnormal: 2 people, 8.00%
- Arthritis (form of joint disorder that involves inflammation of one or more joints): 2 people, 8.00%
* Approximation only. Some reports may have incomplete information.
Do you take Methimazole and Keppra?
- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously
Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
- Methimazole (8,016 reports)
- Keppra (73,504 reports)
Browse all drug interactions of Methimazole and Keppra:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Methimazole:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Keppra:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Methimazole and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Keppra and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zRelated publications that referenced our studies
- Schattner A, Al-Bewerat A, "Levetiracetam (Keppra), urinary retention and literature search", A fatty cause of renal failure; what is your diagnosis?, 2016 Oct .
- Spengler DC, Montouris GD, Hohler AD, "Levetiracetam as a possible contributor to acute kidney injury", Clinical therapeutics, 2014 Aug .
- Almeida DM, Jean MR, Chystsiakova A, Monahan E, Oliveira SB, Monteiro IM, "Levetiracetam-associated acute pancreatitis in an adolescent with autism: a case report", Pancreas, 2013 Jan .
- Schattner A, Al-Bewerat A, "Levetiracetam (Keppra), urinary retention and literature search", A fatty cause of renal failure; what is your diagnosis?, 2016 Oct .
- Spengler DC, Montouris GD, Hohler AD, "Levetiracetam as a possible contributor to acute kidney injury", Clinical therapeutics, 2014 Aug .
- Almeida DM, Jean MR, Chystsiakova A, Monahan E, Oliveira SB, Monteiro IM, "Levetiracetam-associated acute pancreatitis in an adolescent with autism: a case report", Pancreas, 2013 Jan .
How the study uses the data?
The study uses data from the FDA. It is based on methimazole and levetiracetam (the active ingredients of Methimazole and Keppra, respectively), and Methimazole and Keppra (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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