Midostaurin and Cladribine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Midostaurin (midostaurin) and Cladribine (cladribine). Common drug interactions include malignant neoplasm progression among females and nausea among males.

The phase IV clinical study analyzes what interactions people have when they take Midostaurin and Cladribine. It is created by eHealthMe based on reports of 36 people who take the same drugs from the FDA, and is updated regularly.

What is Midostaurin?

Midostaurin has active ingredients of midostaurin. eHealthMe is studying from 1,137 Midostaurin users. Check the latest studies of Midostaurin.

What is Cladribine?

Cladribine has active ingredients of cladribine. eHealthMe is studying from 2,540 Cladribine users. Check the latest studies of Cladribine.

On Jul, 12, 2026

36 people who take Midostaurin and Cladribine together, and have interactions are studied.

Midostaurin and Cladribine drug interactions.

What are the common drug interactions of Midostaurin and Cladribine, by gender? *:

female:

Malignant neoplasm progression (cancer tumour came back)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Febrile neutropenia (fever with reduced white blood cells)
Interstitial lung disease
Pulmonary hypertension (increase in blood pressure in the lung artery)
Sepsis (a severe blood infection that can lead to organ failure and death)
Acute myeloid leukaemia recurrent (acute cancer in which the bone marrow makes abnormal myeloblast- recurrent)
Colitis (inflammation of colon)
Drug ineffective
Empyema (collection of pus in a cavity in the body)

male:

Nausea (feeling of having an urge to vomit)
Pneumonia
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Hypotension (abnormally low blood pressure)
Pneumonia respiratory syncytial viral (respiratory syncytial virus (rsv) is a very common virus that leads to mild, cold-like symptoms in adults and older healthy children)
Respiratory failure (inadequate gas exchange by the respiratory system)
Dyspnoea (difficult or laboured respiration)
Febrile neutropenia (fever with reduced white blood cells)
Haematotoxicity (toxins that destroy red blood cells)
Leukaemia recurrent (repeat cancer of bone marrow or blood cells)

What are the common drug interactions of Midostaurin and Cladribine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Acute myeloid leukaemia recurrent (acute cancer in which the bone marrow makes abnormal myeloblast- recurrent)
Drug ineffective
Megacolon (a very dilated colon)
Myeloblast percentage decreased (number of immature blood cell, found in bone marrow decreased in concentration)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Retinal haemorrhage (bleeding from retina)
Sepsis (a severe blood infection that can lead to organ failure and death)
Wound secretion

40-49:

Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
Bone marrow failure
Escherichia bacteraemia (presence of bacteria escherichia coli in the blood)
Malignant neoplasm progression (cancer tumour came back)
Pyrexia (fever)
Skin lesion
Acute myeloid leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts)
Anaemia (lack of blood)
Anal inflammation
Cardiac failure

50-59:

Acute myocardial infarction (acute heart attack)
Bacteraemia (presence of bacteria in the blood)
Duodenal ulcer
Endocarditis (inflammation in heart muscle)
Epistaxis (bleed from the nose)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Hypotension (abnormally low blood pressure)
Pneumonia respiratory syncytial viral (respiratory syncytial virus (rsv) is a very common virus that leads to mild, cold-like symptoms in adults and older healthy children)
Respiratory failure (inadequate gas exchange by the respiratory system)
Dyspnoea (difficult or laboured respiration)

60+:

Nausea (feeling of having an urge to vomit)
Pneumonia
Malignant neoplasm progression (cancer tumour came back)
Pulmonary hypertension (increase in blood pressure in the lung artery)
Weight decreased
Haematotoxicity (toxins that destroy red blood cells)
Thrombocytopenia (decrease of platelets in blood)
Colitis (inflammation of colon)
Empyema (collection of pus in a cavity in the body)
Hyperbilirubinaemia (excess of bilirubin in the blood)

What are the existing conditions these people have? *

Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 14 people, 38.89%
Systemic Mastocytosis (a condition caused by the accumulation of mast cells in more than one part of the body): 13 people, 36.11%
Pneumonia: 8 people, 22.22%
Depression: 8 people, 22.22%
Mastocytic Leukaemia (presence of large numbers of tissue mast cells in the peripheral blood without skin lesions): 6 people, 16.67%
Nausea And Vomiting: 5 people, 13.89%
Pulmonary Embolism (blockage of the main artery of the lung): 2 people, 5.56%

* Approximation only. Some reports may have incomplete information.

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