Platinol and Benadryl drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Platinol (cisplatin) and Benadryl (diphenhydramine hydrochloride). Common drug interactions include flushing among females and death among males.

The phase IV clinical study analyzes what interactions people have when they take Platinol and Benadryl. It is created by eHealthMe based on reports of 45 people who take the same drugs from the FDA, and is updated regularly.

What is Platinol?

Platinol has active ingredients of cisplatin. eHealthMe is studying from 1,249 Platinol users. Check the latest studies of Platinol.

What is Benadryl?

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. eHealthMe is studying from 104,954 Benadryl users. Check the latest studies of Benadryl.

On Jul, 12, 2026

45 people who take Platinol and Benadryl together, and have interactions are studied.

Platinol and Benadryl drug interactions.

What are the common drug interactions of Platinol and Benadryl, by gender? *:

female:

Flushing (the warm, red condition of human skin)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Gingival disorder (gum disease)
Hypoaesthesia (reduced sense of touch or sensation)
Hypoaesthesia oral (reduced sense of touch or sensation in mouth)
Ileus (a painful obstruction of the ileum or other part of the intestine)
Injection site erythema (redness at injection site)
Injection site haemorrhage (bleeding from injection site)
Injection site oedema
Injection site pain

male:

Death
Disease progression
Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi)
Cardiac failure congestive
Chest discomfort
Chills (felling of cold)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Cough
Drug eruption (adverse drug reaction of the skin)
Dyspnoea (difficult or laboured respiration)

What are the common drug interactions of Platinol and Benadryl, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Asthenia (weakness)
Catheter site infection (infection at the site of insertion)
Fatigue (feeling of tiredness)
Headache (pain in head)
Loss of consciousness
Meningitis aseptic (a condition that causes the membranes covering your brain and spinal cord to become inflamed)
Mobility decreased (ability to move is reduced)
Nausea (feeling of having an urge to vomit)
Photophobia (extreme sensitivity to light)
Respiratory failure (inadequate gas exchange by the respiratory system)

30-39:

Alopecia (absence of hair from areas of the body)
Hair colour changes
Hair disorder

40-49:

Alopecia (absence of hair from areas of the body)
Hair colour changes
Hair disorder
Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi)
Rash
Urticaria (rash of round, red welts on the skin that itch intensely)

50-59:

Nausea (feeling of having an urge to vomit)
Blood creatinine increased
Aphasia (damage to the parts of the brain that control language)
Hair colour changes
Urinary incontinence (inability to control the flow of urine and involuntary urination)
Vomiting
Eosinophil count decreased
Haematocrit decreased
Haemoglobin decreased
Lymphocyte count decreased

60+:

Disease progression
Pleuritic pain
Metastasis (spreadable cancer to other organ from origin)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Psychological trauma
Rash erythematous (redness of the skin)
Recurrent cancer (repeated cancer)
Urinary tract infection
Rash maculo-papular (red area on the skin that is covered with small confluent bumps)
Confusional state

What are the existing conditions these people have? *

Ovarian Cancer (cancer of ovary): 8 people, 17.78%
Breast Cancer Female: 3 people, 6.67%

* Approximation only. Some reports may have incomplete information.

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