Ritalin and Metaxalone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ritalin (methylphenidate hydrochloride) and Metaxalone (metaxalone). Common drug interactions include colonoscopy among females and fatigue among males.

The phase IV clinical study analyzes what interactions people have when they take Ritalin and Metaxalone. It is created by eHealthMe based on reports of 67 people who take the same drugs from the FDA, and is updated regularly.

What is Ritalin?

Ritalin has active ingredients of methylphenidate hydrochloride. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 29,427 Ritalin users. Check the latest studies of Ritalin.

What is Metaxalone?

Metaxalone has active ingredients of metaxalone. It is often used in back pain. eHealthMe is studying from 4,452 Metaxalone users. Check the latest studies of Metaxalone.

On Jul, 15, 2026

67 people who take Ritalin and Metaxalone together, and have interactions are studied.

Ritalin and Metaxalone drug interactions.

What are the common drug interactions of Ritalin and Metaxalone, by gender? *:

female:

Colonoscopy
Constipation
Diabetes mellitus inadequate control
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)
Dizziness
Drug dependence
Drug hypersensitivity
Dysgraphia (impaired ability to learn to write)
Dysphonia (speech disorder attributable to a disorder of phonation)
Dystonia (abnormal muscle tone)

male:

Fatigue (feeling of tiredness)
Intervertebral disc protrusion (spinal disc protrusion)
Anger
Anxiety
Back injury
Breast enlargement
Constipation
Deafness
Disturbance in attention
Drug ineffective

What are the common drug interactions of Ritalin and Metaxalone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Aggression
Agitation (state of anxiety or nervous excitement)
Anger
Anxiety
Breast enlargement
Constipation
Deafness
Disturbance in attention
Drug ineffective
Erection increased

20-29:

n/a

30-39:

Intervertebral disc protrusion (spinal disc protrusion)
Nasopharyngitis (inflammation of the nasopharynx)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Cough
Craniocerebral injury (injury to cranium and brain)
Depressive symptom
Gastric bypass
Oropharyngeal pain
Suicidal ideation

40-49:

Swelling

50-59:

Fatigue (feeling of tiredness)
Hospitalisation
Influenza like illness
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Nasopharyngitis (inflammation of the nasopharynx)
Nephrolithiasis (calculi in the kidneys)
Pain
Rhinorrhoea (watery mucus discharge from the nose)
Sneezing
Therapeutic response unexpected

60+:

Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Dyspnoea (difficult or laboured respiration)
Alanine aminotransferase increased
Anxiety
Anxiety disorder
Arthralgia (joint pain)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Aspartate aminotransferase increased
Atelectasis (partial or complete collapse of the lung)
Carbon dioxide increased

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 46 people, 68.66%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 28 people, 41.79%
Insomnia (sleeplessness): 12 people, 17.91%

* Approximation only. Some reports may have incomplete information.

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