Sinemet cr and Acetaminophen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sinemet cr (carbidopa; levodopa) and Acetaminophen (acetaminophen). Common drug interactions include abdominal pain among females and dyskinesia among males.

The phase IV clinical study analyzes what interactions people have when they take Sinemet cr and Acetaminophen. It is created by eHealthMe based on reports of 47 people who take the same drugs from the FDA, and is updated regularly.

What is Sinemet cr?

Sinemet cr has active ingredients of carbidopa; levodopa. It is often used in parkinson's disease. eHealthMe is studying from 2,852 Sinemet cr users. Check the latest studies of Sinemet cr.

What is Acetaminophen?

Acetaminophen has active ingredients of acetaminophen. It is often used in pain. eHealthMe is studying from 183,077 Acetaminophen users. Check the latest studies of Acetaminophen.

On Jul, 27, 2026

47 people who take Sinemet cr and Acetaminophen together, and have interactions are studied.

Sinemet cr and Acetaminophen drug interactions.

What are the common drug interactions of Sinemet Cr and Acetaminophen, by gender? *:

female:

Abdominal pain
Accident
Bradyphrenia (neurological term referring to the slowness of thought common to many disorders of the brain)
Crying
Eye disorder
Faecaloma (hard mass of fecal matter)
Flat affect (absence of emotional response to a situation)
Medical device discomfort (difficulty due to medical devices)
Mobility decreased (ability to move is reduced)
Muscle rigidity (muscle stiffness)

male:

Dyskinesia (abnormality or impairment of voluntary movement)
Hospitalisation
Drug ineffective
Neutropenia (an abnormally low number of neutrophils)
Weight increased
Hyperkinesia (higher than normal levels of potassium in the circulating blood; associated with kidney failure or sometimes with the use of diuretic drugs)
Abnormal dreams
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Dyspnoea (difficult or laboured respiration)
Fall

What are the common drug interactions of Sinemet Cr and Acetaminophen, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Blood creatine phosphokinase increased

60+:

Dyskinesia (abnormality or impairment of voluntary movement)
Device dislocation
Depressed mood
Hallucination (an experience involving the perception of something not present)
Neutropenia (an abnormally low number of neutrophils)
Emergency care
Hospitalisation
Mobility decreased (ability to move is reduced)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Arthralgia (joint pain)

What are the existing conditions these people have? *

Depression: 3 people, 6.38%

* Approximation only. Some reports may have incomplete information.

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