Synthroid and L-methylfolate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Synthroid (levothyroxine sodium) and L-methylfolate (folic acid). Common drug interactions include fatigue among females and therapeutic response unexpected among males.

The phase IV clinical study analyzes what interactions people have when they take Synthroid and L-methylfolate. It is created by eHealthMe based on reports of 41 people who take the same drugs from the FDA, and is updated regularly.

What is Synthroid?

Synthroid has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. eHealthMe is studying from 249,198 Synthroid users. Check the latest studies of Synthroid.

What is L-methylfolate?

L-methylfolate has active ingredients of folic acid. It is often used in depression. eHealthMe is studying from 619 L-methylfolate users. Check the latest studies of L-methylfolate.

On Jul, 23, 2026

41 people who take Synthroid and L-methylfolate together, and have interactions are studied.

Synthroid and L-methylfolate drug interactions.

What are the common drug interactions of Synthroid and L-Methylfolate, by gender? *:

female:

Fatigue (feeling of tiredness)
Headache (pain in head)
Insomnia (sleeplessness)
Migraine (headache)
Oedema (fluid collection in tissue)
Rash
Sinusitis (inflammation of sinus)
Acute myocardial infarction (acute heart attack)
Agitation (state of anxiety or nervous excitement)
Anxiety

male:

Therapeutic response unexpected
Cardiac procedure complication
Injury
Low density lipoprotein increased (cholesterol increased in blood)
Somnambulism (sleep walking)

What are the common drug interactions of Synthroid and L-Methylfolate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Cardiac disorder
Cellulitis (infection under the skin)
Dehydration (dryness resulting from the removal of water)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Fatigue (feeling of tiredness)
Headache (pain in head)
Insomnia (sleeplessness)
Lupus nephritis (a chronic inflammatory autoimmune disorder that may affect kidney tissue)
Malnutrition (a condition that results from eating a diet in which certain nutrients are lacking)
Muscular weakness (muscle weakness)

30-39:

n/a

40-49:

Acute myocardial infarction (acute heart attack)
Pulmonary embolism (blockage of the main artery of the lung)
Headache (pain in head)
Heart rate increased
Migraine (headache)
Nausea (feeling of having an urge to vomit)
Palpitations (feelings or sensations that your heart is pounding or racing)
Vomiting

50-59:

Seizure (abnormal excessive or synchronous neuronal activity in the brain)

60+:

Glomerular filtration rate decreased
Herpes zoster
Depressed mood
Dysarthria (speech disorder)
Exfoliative rash (scaly red generalized skin rash)
Gastrointestinal hypermotility (over activity of the intestinal tract)
Hand deformity
Ill-defined disorder
Influenza
Injection site pruritus (severe itching at injection site)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 10 people, 24.39%
Stress And Anxiety: 5 people, 12.20%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 9.76%
Pain: 4 people, 9.76%
Immunodeficiency Common Variable: 4 people, 9.76%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 4 people, 9.76%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 7.32%
Migraine Without Aura (headache without neurological problems): 3 people, 7.32%
Immunodeficiency: 3 people, 7.32%
High Blood Pressure: 3 people, 7.32%

* Approximation only. Some reports may have incomplete information.

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