Tapentadol and Naproxen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tapentadol (tapentadol) and Naproxen (naproxen). Common drug interactions include anaemia among females and fall among males.

The phase IV clinical study analyzes what interactions people have when they take Tapentadol and Naproxen. It is created by eHealthMe based on reports of 46 people who take the same drugs from the FDA, and is updated regularly.

What is Tapentadol?

Tapentadol has active ingredients of tapentadol. It is often used in chronic pain. eHealthMe is studying from 2,551 Tapentadol users. Check the latest studies of Tapentadol.

What is Naproxen?

Naproxen has active ingredients of naproxen. It is often used in pain. eHealthMe is studying from 72,032 Naproxen users. Check the latest studies of Naproxen.

On Jul, 07, 2026

46 people who take Tapentadol and Naproxen together, and have interactions are studied.

Tapentadol and Naproxen drug interactions.

What are the common drug interactions of Tapentadol and Naproxen, by gender? *:

female:

Anaemia (lack of blood)
Hyperkalaemia (damage to or disease of the kidney)
Polymyalgia rheumatica (pain in many muscles)
Thrombocytosis
Vomiting
Weight decreased
Asthenia (weakness)
Inflammatory marker increased
Drug ineffective
Somnolence (a state of near-sleep, a strong desire for sleep)

male:

Fall
Confusional state
Asthenia (weakness)
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Cerebral atrophy (decrement in size of brain)
Generalised oedema (swelling all over the body)
Haemorrhage intracranial (bleeding within the skull)
Humerus fracture (injury to the upper arm bone)
Lumbar spinal stenosis (a medical condition in which the spinal canal narrows and compresses the spinal cord and nerves at the level of the lumbar bone)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)

What are the common drug interactions of Tapentadol and Naproxen, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Drug ineffective

30-39:

Chest pain
Cluster headache (one-sided head pain with tearing)
Depressed level of consciousness
Disturbance in attention
Hallucination, auditory (perceiving sounds without auditory stimulus)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Speech disorder

40-49:

Confusional state
Constipation
Malaise (a feeling of general discomfort or uneasiness)
Somnolence (a state of near-sleep, a strong desire for sleep)
Drug intolerance (drug sensitivity)
Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
Drug ineffective

50-59:

Confusional state
Delirium (wild excitement)
Loss of consciousness
Retrograde amnesia (a loss of memory-access to events that occurred, or information that was learned, before an injury or the onset of a disease)
Transaminases increased
Pyrexia (fever)
Allodynia (a condition in which pain is caused by a stimulus that does not normally elicit pain)
Apnoea (suspension of external breathing)
Bradycardia (abnormally slow heart action)
Diarrhoea

60+:

Anaemia (lack of blood)
Hyperkalaemia (damage to or disease of the kidney)
Pneumonitis (inflammation of the walls of the alveoli in the lungs)
Head injury
Infective aneurysm (infective bulge or ""ballooning"" in the wall of an artery)
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Cerebral atrophy (decrement in size of brain)
Generalised oedema (swelling all over the body)
Haemorrhage intracranial (bleeding within the skull)
Humerus fracture (injury to the upper arm bone)

What are the existing conditions these people have? *

Pain In Extremity: 5 people, 10.87%
Gait Disturbance: 5 people, 10.87%
Polymyalgia Rheumatica (pain in many muscles): 4 people, 8.70%
Primary Progressive Multiple Sclerosis (primary progressive inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 3 people, 6.52%

* Approximation only. Some reports may have incomplete information.

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