Vesicare and Dilantin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Vesicare (solifenacin succinate) and Dilantin (phenytoin sodium). Common drug interactions include fatigue among females and akathisia among males.

The phase IV clinical study analyzes what interactions people have when they take Vesicare and Dilantin. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.

What is Vesicare?

Vesicare has active ingredients of solifenacin succinate. It is often used in urge incontinence. eHealthMe is studying from 30,655 Vesicare users. Check the latest studies of Vesicare.

What is Dilantin?

Dilantin has active ingredients of phenytoin sodium. It is often used in epilepsy. eHealthMe is studying from 20,859 Dilantin users. Check the latest studies of Dilantin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

19 people who take Vesicare and Dilantin together, and have interactions are studied.

Vesicare and Dilantin drug interactions.

What are the common drug interactions of Vesicare and Dilantin, by gender? *:

female:

Fatigue (feeling of tiredness)
Foot deformity (functional disability of foot)
Gastritis (inflammation of stomach)
Gastroenteritis (inflammation of stomach and intestine)
Gastrointestinal angiodysplasia (a small vascular malformation of the gut)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Glucose tolerance impaired (blood glucose is raised beyond normal levels, but not high enough to warrant a diabetes diagnosis)
Haematuria (presence of blood in urine)
Headache (pain in head)

male:

Akathisia (a movement disorder characterized by a feeling of inner restlessness)
Anxiety
Drug diversion
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Dry mouth
Dysaesthesia (abnormal sensation)
Dysarthria (speech disorder)
Dysphagia (a condition in which swallowing is difficult or painful)
Dysphonia (speech disorder attributable to a disorder of phonation)
Dyspnoea (difficult or laboured respiration)

What are the common drug interactions of Vesicare and Dilantin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)

40-49:

n/a

50-59:

Fatigue (feeling of tiredness)
Foot deformity (functional disability of foot)
Gastritis (inflammation of stomach)
Gastroenteritis (inflammation of stomach and intestine)
Gastrointestinal angiodysplasia (a small vascular malformation of the gut)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Glucose tolerance impaired (blood glucose is raised beyond normal levels, but not high enough to warrant a diabetes diagnosis)
Haematuria (presence of blood in urine)
Headache (pain in head)

60+:

Dyspnoea (difficult or laboured respiration)
Anaphylactic reaction (serious allergic reaction)
Diarrhoea
Diastolic dysfunction
Diverticulum intestinal (a pouch that is attached to the first part of the small intestine)
Dizziness
Drug diversion
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Dysaesthesia (abnormal sensation)
Dysarthria (speech disorder)

What are the existing conditions these people have? *

Urinary Incontinence (inability to control the flow of urine and involuntary urination): 6 people, 31.58%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 4 people, 21.05%
Allergy To Arthropod Sting: 3 people, 15.79%
High Blood Cholesterol: 3 people, 15.79%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 3 people, 15.79%
Petit Mal Epilepsy (absence seizure): 3 people, 15.79%
Depression: 3 people, 15.79%
Dyspnea (difficult or laboured breathing): 2 people, 10.53%
Stress And Anxiety: 2 people, 10.53%
Wheezing (a high-pitched whistling sound made while you breath): 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

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