Zanaflex and Serzone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zanaflex (tizanidine hydrochloride) and Serzone (nefazodone hydrochloride). Common drug interactions include back pain among females and drug dependence among males.

The phase IV clinical study analyzes what interactions people have when they take Zanaflex and Serzone. It is created by eHealthMe based on reports of 79 people who take the same drugs from the FDA, and is updated regularly.

What is Zanaflex?

Zanaflex has active ingredients of tizanidine hydrochloride. It is often used in muscle spasms. eHealthMe is studying from 17,476 Zanaflex users. Check the latest studies of Zanaflex.

What is Serzone?

Serzone has active ingredients of nefazodone hydrochloride. It is often used in depression. eHealthMe is studying from 7,695 Serzone users. Check the latest studies of Serzone.

On Jul, 06, 2026

79 people who take Zanaflex and Serzone together, and have interactions are studied.

What are the common drug interactions of Zanaflex and Serzone, by gender? *:

female:

Back pain
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Dizziness
Dysphagia (a condition in which swallowing is difficult or painful)
Dyspnoea (difficult or laboured respiration)
Fall
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Pulmonary congestion (congestion in the lungs)
Acute coronary syndrome (acute chest pain and other symptoms that happen because the heart does not get blood)
Diarrhoea

male:

Drug dependence
Drug tolerance increased
Vomiting
Gun shot wound
Mouth haemorrhage (bleeding from mouth)
Pancreatitis acute (sudden inflammation of pancreas)
Rash
Suicidal ideation
Suicide attempt
Completed suicide (act of taking one's own life)

What are the common drug interactions of Zanaflex and Serzone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Drug dependence
Drug tolerance increased
Gun shot wound
Mouth haemorrhage (bleeding from mouth)
Completed suicide (act of taking one's own life)
Drug addiction
Intentional self-injury
Drug screen positive
Emotional disorder
Head injury

30-39:

Nausea (feeling of having an urge to vomit)
Vomiting
Constipation
Abdominal pain
Anal fissure
Coeliac disease (simple food intolerance)
Diarrhoea
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Gastritis (inflammation of stomach)
Rectal haemorrhage (bleeding from anus)

40-49:

Chest pain
Diarrhoea
Insomnia (sleeplessness)
Drug dependence
Drug ineffective
Gastritis (inflammation of stomach)
Chest discomfort
Headache (pain in head)
Nausea (feeling of having an urge to vomit)
Pyrexia (fever)

50-59:

Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Reading disorder (problem in areas of the brain that help interpret language)
Tenderness (pain or discomfort when an affected area is touched)
Thrombosis (formation of a blood clot inside a blood vessel)
Aortic atherosclerosis (degenerative process of aortic arteries)
Bone pain
Cardiac disorder
Cerebral haemorrhage (bleeding within the brain)
Cerebral infarction (less blood supply to brain resulting tissue damage)
Drug effect decreased

60+:

Dizziness
Drug dependence
Dyspepsia (indigestion)
Hypertension (high blood pressure)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Ulcer
Vomiting
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Chronic kidney disease
Confusional state

What are the existing conditions these people have? *

Pain: 17 people, 21.52%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 11 people, 13.92%
Joint Pain: 7 people, 8.86%
Back Pain: 6 people, 7.59%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 5 people, 6.33%
Restless Leg Syndrome (a powerful urge to move your legs): 4 people, 5.06%
Bipolar Disorder (mood disorder): 4 people, 5.06%

* Approximation only. Some reports may have incomplete information.

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