Zestril and Vyvanse drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zestril (lisinopril) and Vyvanse (lisdexamfetamine dimesylate). Common drug interactions include abdominal distension among females and therapeutic response unexpected among males.

The phase IV clinical study analyzes what interactions people have when they take Zestril and Vyvanse. It is created by eHealthMe based on reports of 18 people who take the same drugs from the FDA, and is updated regularly.

What is Zestril?

Zestril has active ingredients of lisinopril. It is often used in high blood pressure. eHealthMe is studying from 22,273 Zestril users. Check the latest studies of Zestril.

What is Vyvanse?

Vyvanse has active ingredients of lisdexamfetamine dimesylate. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 35,868 Vyvanse users. Check the latest studies of Vyvanse.

On Jul, 21, 2026

18 people who take Zestril and Vyvanse together, and have interactions are studied.

What are the common drug interactions of Zestril and Vyvanse, by gender? *:

female:

Abdominal distension
Asthma
Facial paralysis (loss of function of face muscle)
Folliculitis (infection of hair root)
Heart rate increased
Influenza
Infusion site erythema (reddening of the skin at infusion site)
Infusion site pruritus (severe itching at infusion site)
Malaise (a feeling of general discomfort or uneasiness)
Oral surgery

male:

Therapeutic response unexpected
Anger
Anxiety
Chronic kidney disease

What are the common drug interactions of Zestril and Vyvanse, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Anger
Anxiety
Chronic kidney disease

50-59:

Breast injury
Infusion site pruritus (severe itching at infusion site)
Malaise (a feeling of general discomfort or uneasiness)
Oral surgery
Sinus disorder (disease of sinus)
Sinusitis (inflammation of sinus)
Skin infection
Upper respiratory tract infection
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Ovarian neoplasm (tumour of ovary)

60+:

Therapeutic response unexpected

What are the existing conditions these people have? *

Cataplexy (loss of muscle tone accompanied by full conscious awareness): 6 people, 33.33%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 6 people, 33.33%
Immunodeficiency Common Variable: 5 people, 27.78%
Fatigue (feeling of tiredness): 4 people, 22.22%
Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 4 people, 22.22%
Pain: 4 people, 22.22%
Trigeminal Neuralgia (a painful condition of the nerve responsible for most facial sensation): 4 people, 22.22%
Wheezing (a high-pitched whistling sound made while you breath): 1 person, 5.56%
Bipolar Disorder (mood disorder): 1 person, 5.56%
Cough: 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

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