Zetia and Narcan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zetia (ezetimibe) and Narcan (naloxone hydrochloride). Common drug interactions include asthenia among females and back pain among males.

The phase IV clinical study analyzes what interactions people have when they take Zetia and Narcan. It is created by eHealthMe based on reports of 39 people who take the same drugs from the FDA, and is updated regularly.

What is Zetia?

Zetia has active ingredients of ezetimibe. It is often used in high blood cholesterol. eHealthMe is studying from 49,113 Zetia users. Check the latest studies of Zetia.

What is Narcan?

Narcan has active ingredients of naloxone hydrochloride. eHealthMe is studying from 3,687 Narcan users. Check the latest studies of Narcan.



On Jul, 27, 2026

39 people who take Zetia and Narcan together, and have interactions are studied.

Zetia and Narcan drug interactions.

What are the common drug interactions of Zetia and Narcan, by gender? *:

female:

  1. Asthenia (weakness)
  2. Back pain
  3. Bone disorder
  4. Bone lesion (bone with abnormalities. bone lesions can result from growth formations, infections, or injuries)
  5. Chest pain
  6. Choking (mechanical obstruction of the flow of air from the environment into the lungs)
  7. Conjunctival haemorrhage (bleeding underneath the conjunctiva)
  8. Constipation
  9. Cough
  10. Deafness

male:

  1. Back pain
  2. Chronic kidney disease
  3. Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
  4. Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
  5. Blood creatinine increased
  6. Blood glucose increased
  7. Blood urine present
  8. Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
  9. Cardiac arrest
  10. Cardiac failure congestive

What are the common drug interactions of Zetia and Narcan, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

  1. Haemorrhage (bleeding)
  2. Hepatic cyst
  3. Hepatic steatosis (fatty liver disease)
  4. Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
  5. Hyperglycaemia (high blood sugar)
  6. Hypersensitivity
  7. Hypopnoea (decrease in the breathing rate)
  8. Impaired healing
  9. Injury
  10. Lentigo (a small pigmented spot on the skin with a clearly-defined edge, surrounded by normal-appearing skin)

60+:

  1. Abdominal pain
  2. Chronic kidney disease
  3. Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
  4. Cardiomyopathy (weakening of the heart muscle)
  5. Chills (felling of cold)
  6. Cholecystitis infective (infection of gallbladder capable to infect other organs)
  7. Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
  8. Dehydration (dryness resulting from the removal of water)
  9. Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
  10. Diarrhoea

What are the existing conditions these people have? *

  1. Osteoporosis (bones weak and more likely to break): 14 people, 35.90%
  2. Diabetes: 14 people, 35.90%
  3. Pain: 14 people, 35.90%
  4. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 12 people, 30.77%
  5. Muscle Spasms (muscle contraction): 11 people, 28.21%
  6. High Blood Pressure: 11 people, 28.21%
  7. Fungal Infection: 10 people, 25.64%
  8. Nausea (feeling of having an urge to vomit): 10 people, 25.64%
  9. Nasopharyngitis (inflammation of the nasopharynx): 10 people, 25.64%
  10. Cough: 10 people, 25.64%

* Approximation only. Some reports may have incomplete information.

Do you take Zetia and Narcan?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Zetia and Narcan:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Zetia:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Narcan:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Zetia and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Narcan and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on ezetimibe and naloxone hydrochloride (the active ingredients of Zetia and Narcan, respectively), and Zetia and Narcan (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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