Aleve and Osteosclerosis - a phase IV clinical study of FDA data

Summary:

Osteosclerosis is reported as a side effect among people who take Aleve (naproxen sodium), especially for people who are female, 40-49 old, also take Zometa, and have Metastases to bone.

The phase IV clinical study analyzes which people have Osteosclerosis when taking Aleve. It is created by eHealthMe based on reports of 68,206 people who have side effects when taking Aleve from the FDA, and is updated regularly.

What is Aleve?

Aleve has active ingredients of naproxen sodium. It is often used in pain. eHealthMe is studying from 70,279 Aleve users. Check the latest studies of Aleve.

What is Osteosclerosis?

Osteosclerosis (an elevation in bone density) is found to be associated with 635 drugs and 399 conditions by eHealthMe. Check the latest studies of Osteosclerosis.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 30, 2026

68,206 people reported to have side effects when taking Aleve.
Among them, 37 people (0.05%) have Osteosclerosis.

Among these 37 people:

What is the gender of people who have Osteosclerosis when taking Aleve? *

female: 59.46 %
male: 40.54 %

What is the age of people who have Osteosclerosis when taking Aleve? *

What are other drugs people take besides Aleve? *

What are other side effects people have besides Osteosclerosis? *

Osteomyelitis (infection of bone): 29 people, 78.38%
Rashes (redness): 27 people, 72.97%
Osteonecrosis Of Jaw (death of bone of jaw): 27 people, 72.97%
Pain In Jaw: 27 people, 72.97%
Chest Pain: 23 people, 62.16%
Hypoaesthesia (reduced sense of touch or sensation): 22 people, 59.46%
Periodontal Disease (disease that attacks the gum and bone and around the teeth): 21 people, 56.76%
Bone Disorder: 21 people, 56.76%
Metastases To Bone (cancer spreads to bone): 21 people, 56.76%
Anaemia (lack of blood): 21 people, 56.76%

What are the existing conditions these people have? *

Metastases To Bone (cancer spreads to bone): 17 people, 45.95%
Multiple Myeloma (cancer of the plasma cells): 9 people, 24.32%
Hypercalcaemia (elevated calcium (ca+) level in the blood): 8 people, 21.62%
Breast Cancer: 7 people, 18.92%
Neoplasm Malignant (cancer tumour): 7 people, 18.92%
Pain In Jaw: 6 people, 16.22%
Depression: 6 people, 16.22%
Prostate Cancer Metastatic: 4 people, 10.81%
Stress And Anxiety: 3 people, 8.11%
Breast Cancer Metastatic: 2 people, 5.41%

* Approximation only. Some reports may have incomplete information.

Do you take Aleve and have Osteosclerosis?

- Check whether Osteosclerosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Aleve:

Aleve (70,279 reports)

Osteosclerosis treatments and more:

Osteosclerosis (2,741 reports)

Browse all side effects of Aleve:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Osteosclerosis:

Osteosclerosis (635 drugs)

Browse all the conditions that are associated with Osteosclerosis:

Osteosclerosis (399 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on naproxen sodium (the active ingredients of Aleve) and Aleve (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.