Depakote and Swelling - a phase IV clinical study of FDA data
Summary:
Swelling is found among people who take Depakote, especially for people who are female, 40-49 old, have been taking the drug for < 1 month.
The phase IV clinical study analyzes which people take Depakote and have Swelling. It is created by eHealthMe based on reports of 49,884 people who have side effects when taking Depakote from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.
Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.
49,884 people reported to have side effects when taking Depakote.
Among them, 238 people (0.48%) have Swelling.
What is Depakote?
Depakote has active ingredients of divalproex sodium. It is often used in bipolar disorder. eHealthMe is studying from 52,749 Depakote users for its effectiveness, alternative drugs and more.
What is Swelling?
Swelling is found to be associated with 3,339 drugs and 2,736 conditions by eHealthMe.
Number of Depakote and Swelling reports submitted per year:

Time on Depakote when people have Swelling *:
Gender of people who have Swelling when taking Depakote*:
Age of people who have Swelling when taking Depakote *:
Common drugs people take besides Depakote *:
Common side effects people have besides Swelling *:
Common conditions people have *:
* Approximation only. Some reports may have incomplete information.
Do you take Depakote and have Swelling?
Check whether Swelling is associated with a drug or a conditionHow to use the study?
You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.
Related studies
How severe was Swelling and when was it recovered:
Expand to all the drugs that have ingredients of divalproex sodium:
- Swelling and drugs with ingredients of divalproex sodium (161 reports)
Alternative drugs to, pros and cons of Depakote:
- Depakote (52,749 reports)
Common Depakote side effects:
- Weight increased: 2,766 reports
- Fatigue (feeling of tiredness): 2,716 reports
- Drug ineffective: 2,665 reports
- Stress and anxiety: 2,513 reports
- Pain: 2,310 reports
- Drowsiness: 2,191 reports
- Tremor (trembling or shaking movements in one or more parts of your body): 2,179 reports
Browse all side effects of Depakote:
a b c d e f g h i j k l m n o p q r s t u v w x y zSwelling treatments and more:
- Swelling (97,714 reports)
COVID vaccines that are related to Swelling:
- Swelling in Moderna COVID Vaccine
- Swelling in Pfizer BioNTech Covid Vaccine
- Swelling in Johnson and Johnson Covid Vaccine
Common drugs associated with Swelling:
- Methotrexate: 13,315 reports
- Enbrel: 12,839 reports
- Prednisone: 12,763 reports
- Humira: 11,342 reports
- Actemra: 8,788 reports
- Orencia: 8,551 reports
- Arava: 7,998 reports
- Xeljanz: 7,898 reports
- Sulfasalazine: 7,291 reports
- Remicade: 7,189 reports
All the drugs that are associated with Swelling:
- Swelling (3,339 drugs)
Common conditions associated with Swelling:
- Rheumatoid arthritis: 17,652 reports
- High blood pressure: 3,582 reports
- Pain: 3,389 reports
- Primary pulmonary hypertension: 3,059 reports
- Multiple sclerosis: 2,325 reports
All the conditions that are associated with Swelling:
- Swelling (2,736 conditions)
How the study uses the data?
The study uses data from the FDA. It is based on divalproex sodium (the active ingredients of Depakote) and Depakote (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
Who is eHealthMe?
With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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