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Indomethacin and Sinus node dysfunction - a phase IV clinical study of FDA data

Summary:

Sinus node dysfunction is reported as a side effect among people who take Indomethacin (indomethacin), especially for people who are female, 60+ old, also take Prednisolone, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Sinus node dysfunction when taking Indomethacin. It is created by eHealthMe based on reports of 16,214 people who have side effects when taking Indomethacin from the FDA, and is updated regularly.

What is Indomethacin?

Indomethacin has active ingredients of indomethacin. It is often used in gout. eHealthMe is studying from 16,883 Indomethacin users. Check the latest studies of Indomethacin.

What is Sinus node dysfunction?

Sinus node dysfunction (a group of abnormal heart rhythms) is found to be associated with 1,183 drugs and 840 conditions by eHealthMe. Check the latest studies of Sinus node dysfunction.

On Jan, 26, 2026

16,214 people reported to have side effects when taking Indomethacin.
Among them, 12 people (0.07%) have Sinus node dysfunction.

Could Indomethacin cause Sinus node dysfunction?

Among these 12 people:

What is the gender of people who have Sinus node dysfunction when taking Indomethacin? *

  • female: 75 %
  • male: 25 %

What is the age of people who have Sinus node dysfunction when taking Indomethacin? *

  • 0-1: 9.09 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 9.09 %
  • 60+: 81.82 %

What are other drugs people take besides Indomethacin? *

  1. Alendronate Sodium: 6 people, 50.00%
  2. Methotrexate: 6 people, 50.00%
  3. Prednisolone: 6 people, 50.00%
  4. Flurbiprofen: 5 people, 41.67%
  5. Triamcinolone Acetonide: 5 people, 41.67%
  6. Nabumetone: 5 people, 41.67%
  7. Famotidine: 5 people, 41.67%
  8. Ketoprofen: 5 people, 41.67%
  9. Humira: 5 people, 41.67%
  10. Diclofenac Sodium: 5 people, 41.67%

What are other side effects people have besides Sinus node dysfunction? *

  1. Disseminated Intravascular Coagulation (systemic activation of blood coagulation): 5 people, 41.67%
  2. Cerebral Infarction (less blood supply to brain resulting tissue damage): 5 people, 41.67%
  3. Visual Impairment: 5 people, 41.67%
  4. Arterial Haemorrhage: 5 people, 41.67%
  5. Hypovolaemic Shock (shock caused by severe blood or fluid loss): 5 people, 41.67%
  6. Brain Herniation (brain herniation is a potentially deadly side effect of very high intracranial pressure that occurs when a part of the brain is squeezed across structures within the skull): 5 people, 41.67%
  7. Brain Oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain): 5 people, 41.67%
  8. Breathing - Slowed Or Stopped: 5 people, 41.67%
  9. Subarachnoid Haemorrhage (blood leaks into the space between two membranes that surround the brain): 5 people, 41.67%
  10. Left Ventricular Hypertrophy (the thickening of the myocardium (muscle) of the left ventricle of the heart): 3 people, 25.00%

What are the existing conditions these people have? *

  1. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 6 people, 50.00%
  2. Adverse Drug Reaction: 3 people, 25.00%
  3. Type 2 Diabetes: 1 person, 8.33%
  4. Trigeminal Neuralgia (a painful condition of the nerve responsible for most facial sensation): 1 person, 8.33%
  5. Osteoporosis (bones weak and more likely to break): 1 person, 8.33%
  6. Osteopenia (a condition where bone mineral density is lower than normal): 1 person, 8.33%
  7. Anaemia (lack of blood): 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Indomethacin and have Sinus node dysfunction?

- Check whether Sinus node dysfunction is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Indomethacin:

Sinus node dysfunction treatments and more:

How severe was Sinus node dysfunction and when was it recovered:

Expand to all the drugs that have ingredients of indomethacin:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Indomethacin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Sinus node dysfunction:

Browse all the conditions that are associated with Sinus node dysfunction:

Drugs similar to Indomethacin and Sinus node dysfunction :

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on indomethacin (the active ingredients of Indomethacin) and Indomethacin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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