Lupron and Spondylolisthesis - a phase IV clinical study of FDA data

Summary:

Spondylolisthesis is reported as a side effect among people who take Lupron (leuprolide acetate), especially for people who are female, 50-59 old, have been taking the drug for 5 - 10 years also take Zometa, and have Metastases to bone.

The phase IV clinical study analyzes which people have Spondylolisthesis when taking Lupron. It is created by eHealthMe based on reports of 41,483 people who have side effects when taking Lupron from the FDA, and is updated regularly.

What is Lupron?

Lupron has active ingredients of leuprolide acetate. It is often used in endometriosis. eHealthMe is studying from 42,122 Lupron users. Check the latest studies of Lupron.

What is Spondylolisthesis?

Spondylolisthesis (displacement of a vertebra or the vertebral column in relation to the vertebrae below) is found to be associated with 566 drugs and 493 conditions by eHealthMe. Check the latest studies of Spondylolisthesis.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

41,483 people reported to have side effects when taking Lupron.
Among them, 33 people (0.08%) have Spondylolisthesis.

Among these 33 people:

How long have people been on Lupron when they have Spondylolisthesis? *

What is the gender of people who have Spondylolisthesis when taking Lupron? *

female: 75 %
male: 25 %

What is the age of people who have Spondylolisthesis when taking Lupron? *

What are other drugs people take besides Lupron? *

What are other side effects people have besides Spondylolisthesis? *

Stress And Anxiety: 32 people, 96.97%
Pain: 32 people, 96.97%
General Physical Health Deterioration (weak health status): 29 people, 87.88%
Intervertebral Disc Protrusion (spinal disc protrusion): 28 people, 84.85%
Osteonecrosis Of Jaw (death of bone of jaw): 27 people, 81.82%
Back Pain: 26 people, 78.79%
Metastases To Spine (cancer spreads to spine): 25 people, 75.76%
Depression: 25 people, 75.76%
Hiatal Hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm): 23 people, 69.70%
Compression Fracture (fracture due to pressure caused by injury): 21 people, 63.64%

What are the existing conditions these people have? *

Metastases To Bone (cancer spreads to bone): 28 people, 84.85%
Depression: 5 people, 15.15%
Osteoporosis (bones weak and more likely to break): 4 people, 12.12%
Anaemia (lack of blood): 4 people, 12.12%
Breast Cancer: 2 people, 6.06%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 1 person, 3.03%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 1 person, 3.03%
Multiple Myeloma (cancer of the plasma cells): 1 person, 3.03%
Joint Pain: 1 person, 3.03%
Hiv Infection: 1 person, 3.03%

* Approximation only. Some reports may have incomplete information.

Do you take Lupron and have Spondylolisthesis?

- Check whether Spondylolisthesis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Lupron:

Lupron (42,122 reports)

Browse all side effects of Lupron:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Spondylolisthesis:

Spondylolisthesis (566 drugs)

Browse all the conditions that are associated with Spondylolisthesis:

Spondylolisthesis (493 conditions)

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on leuprolide acetate (the active ingredients of Lupron) and Lupron (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.