Ultram and Synovitis - a phase IV clinical study of FDA data

Summary:

Synovitis is reported as a side effect among people who take Ultram (tramadol hydrochloride), especially for people who are female, 50-59 old, have been taking the drug for < 1 month also take Remicade, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Synovitis when taking Ultram. It is created by eHealthMe based on reports of 26,802 people who have side effects when taking Ultram from the FDA, and is updated regularly.

What is Ultram?

Ultram has active ingredients of tramadol hydrochloride. It is often used in pain. eHealthMe is studying from 28,425 Ultram users. Check the latest studies of Ultram.

What is Synovitis?

Synovitis (inflammation of the synovial membrane) is found to be associated with 721 drugs and 503 conditions by eHealthMe. Check the latest studies of Synovitis.

On Jan, 07, 2026

26,802 people reported to have side effects when taking Ultram.
Among them, 86 people (0.32%) have Synovitis.

Among these 86 people:

* Approximation only. Some reports may have incomplete information.

Do you take Ultram and have Synovitis?

- Check whether Synovitis is associated with a drug or a condition (FREE)
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- Get an AI agent to monitor your drugs continuously (FREE)

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Ultram:

Ultram (28,425 reports)

Synovitis treatments and more:

Synovitis (24,130 reports)

How severe was Synovitis and when was it recovered:

Synovitis in Ultram

Expand to all the drugs that have ingredients of tramadol hydrochloride:

Synovitis and drugs with ingredients of tramadol hydrochloride (628 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Common Ultram side effects:

Ultram side effect: Nausea (feeling of having an urge to vomit) (2,558 reports)

Browse all side effects of Ultram:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common drugs associated with Synovitis:

Browse all the drugs that are associated with Synovitis:

Synovitis (721 drugs)

Common conditions associated with Synovitis:

Ra: 16,944 reports
Psoriatic arthropathy: 2,837 reports
Psoriasis: 2,098 reports
Crohn's disease: 820 reports
Still's disease: 734 reports
Pain: 687 reports
Alternative medicine - pain relief: 675 reports
Spondylitis: 658 reports
Arthritis: 547 reports
Sle: 503 reports

Browse all the conditions that are associated with Synovitis:

Synovitis (503 conditions)

Drugs similar to Ultram and Synovitis :

Related publications that referenced our studies

Mansour HM, "Tramadol and Disseminated Intravascular Coagulopathy: A Case Report", Medicine Science, 2015 Jan .
Mansour HM, "Tramadol and Disseminated Intravascular Coagulopathy: A Case Report", Medicine Science, 2015 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on tramadol hydrochloride (the active ingredients of Ultram) and Ultram (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.