Epa and Zetia drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Epa (epa (eicosapentaenoic acid)) and Zetia (ezetimibe). Common drug interactions include allergic cough among females and obesity among males.

The phase IV clinical study analyzes what interactions people have when they take Epa and Zetia. It is created by eHealthMe based on reports of 17 people who take the same drugs from the FDA, and is updated regularly.

What is Epa?

Epa has active ingredients of epa (eicosapentaenoic acid). It is often used in high blood cholesterol. eHealthMe is studying from 623 Epa users. Check the latest studies of Epa.

What is Zetia?

Zetia has active ingredients of ezetimibe. It is often used in high blood cholesterol. eHealthMe is studying from 49,113 Zetia users. Check the latest studies of Zetia.



On Jul, 12, 2026

17 people who take Epa and Zetia together, and have interactions are studied.

Epa and Zetia drug interactions.

What are the common drug interactions of Epa and Zetia, by gender? *:

female:

  1. Allergic cough
  2. Anaphylactic shock (severe and rapid and sometimes fatal hypersensitivity reaction to a substance)
  3. Back pain
  4. Dental caries
  5. Diarrhoea
  6. Dry skin
  7. Dyspepsia (indigestion)
  8. Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
  9. Enterocolitis viral
  10. Inflammation

male:

  1. Obesity (having too much body fat)
  2. Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
  3. Cardiac ventricular thrombosis (blood clot in ventricle)
  4. Cytomegalovirus enterocolitis (virus infection of intestine and colon)
  5. Drug intolerance (drug sensitivity)
  6. Dry mouth
  7. Hepatic failure (liver failure)
  8. Low cardiac output syndrome (decreased cardiac output)
  9. Lung cancer metastatic (lung cancer spreads to other parts)
  10. Metastases to liver (cancer spreads to liver)

What are the common drug interactions of Epa and Zetia, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

  1. Acute myocardial infarction (acute heart attack)

40-49:

  1. Obesity (having too much body fat)
  2. Allergic cough
  3. Back pain
  4. Dental caries
  5. Diarrhoea
  6. Dry skin
  7. Dyspepsia (indigestion)
  8. Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
  9. Enterocolitis viral
  10. Iron deficiency anaemia

50-59:

  1. Anaphylactic shock (severe and rapid and sometimes fatal hypersensitivity reaction to a substance)

60+:

  1. Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
  2. Blood glucose increased
  3. Inflammation
  4. Low cardiac output syndrome (decreased cardiac output)
  5. Lung cancer metastatic (lung cancer spreads to other parts)
  6. Metastases to liver (cancer spreads to liver)
  7. Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness)
  8. Muscular weakness (muscle weakness)
  9. Pneumonitis (inflammation of the walls of the alveoli in the lungs)
  10. Renal impairment (severely reduced kidney function)

What are the existing conditions these people have? *

  1. High Blood Pressure: 4 people, 23.53%
  2. Hyperuricaemia (level of uric acid in the blood that is abnormally high): 4 people, 23.53%
  3. Hiv Infection: 3 people, 17.65%
  4. Type 2 Diabetes: 2 people, 11.76%
  5. Insomnia (sleeplessness): 2 people, 11.76%
  6. Dyslipidaemia (abnormal amount of lipids): 2 people, 11.76%
  7. Hepatocellular Carcinoma (liver cancer): 2 people, 11.76%
  8. Hyperlipidaemia (presence of excess lipids in the blood): 2 people, 11.76%
  9. Lung Cancer - Non-Small Cell (lung cancer): 1 person, 5.88%
  10. Lupus Nephritis (a chronic inflammatory autoimmune disorder that may affect kidney tissue): 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

Do you take Epa and Zetia?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Epa and Zetia:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Epa:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Zetia:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Epa and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Zetia and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on epa (eicosapentaenoic acid) and ezetimibe (the active ingredients of Epa and Zetia, respectively), and Epa and Zetia (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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