Lupron and Trulicity drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lupron (leuprolide acetate) and Trulicity (dulaglutide). Common drug interactions include nausea among females and memory impairment among males.

The phase IV clinical study analyzes what interactions people have when they take Lupron and Trulicity. It is created by eHealthMe based on reports of 22 people who take the same drugs from the FDA, and is updated regularly.

What is Lupron?

Lupron has active ingredients of leuprolide acetate. It is often used in endometriosis. eHealthMe is studying from 42,122 Lupron users. Check the latest studies of Lupron.

What is Trulicity?

Trulicity has active ingredients of dulaglutide. It is often used in weight loss. eHealthMe is studying from 77,529 Trulicity users. Check the latest studies of Trulicity.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

22 people who take Lupron and Trulicity together, and have interactions are studied.

What are the common drug interactions of Lupron and Trulicity, by gender? *:

female:

Nausea (feeling of having an urge to vomit)
Blood potassium decreased
Body height decreased
Cough
Dizziness
Lacrimation increased
Paronychia (infection in the tissues adjacent to a nail on a finger or toe)
Rhinorrhoea (watery mucus discharge from the nose)
Spinal fracture (fracture in one of vertebrae)
Vomiting

male:

Memory impairment
Abdominal discomfort
Flushing (the warm, red condition of human skin)
Glycosylated haemoglobin increased
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
Rash vesicular (rash with a small bubble)
Vasculitis (inflammation of a blood vessel or blood vessels)
Vomiting
Aggression
Depressed mood

What are the common drug interactions of Lupron and Trulicity, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Body height decreased
Cough
Lacrimation increased
Nausea (feeling of having an urge to vomit)
Paronychia (infection in the tissues adjacent to a nail on a finger or toe)
Rhinorrhoea (watery mucus discharge from the nose)
Spinal fracture (fracture in one of vertebrae)
White blood cell count decreased

50-59:

Dizziness
Vomiting
Abdominal discomfort
Abdominal pain
Flushing (the warm, red condition of human skin)
Blood potassium decreased
Nausea (feeling of having an urge to vomit)
Neoplasm malignant (cancer tumour)

60+:

Aggression
Depressed mood
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Discomfort
Disease progression
Fatigue (feeling of tiredness)
Heart rate irregular
Malignant melanoma (skin cancer rises from melancytes)
Pain
Prostatic specific antigen increased

What are the existing conditions these people have? *

Prostate Cancer: 13 people, 59.09%
Diabetes: 5 people, 22.73%
Breast Cancer: 3 people, 13.64%
Neoplasm Malignant (cancer tumour): 2 people, 9.09%
Nausea (feeling of having an urge to vomit): 2 people, 9.09%
Indigestion: 2 people, 9.09%
High Blood Pressure: 2 people, 9.09%
Erection Problems: 2 people, 9.09%
Diarrhea: 2 people, 9.09%
Cardiac Failure Congestive: 2 people, 9.09%

* Approximation only. Some reports may have incomplete information.

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