Protriptyline hydrochloride and Aspirin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Protriptyline hydrochloride (protriptyline hydrochloride) and Aspirin (aspirin). Common drug interactions include fall among females and cough among males.

The phase IV clinical study analyzes what interactions people have when they take Protriptyline hydrochloride and Aspirin. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Protriptyline hydrochloride?

Protriptyline hydrochloride has active ingredients of protriptyline hydrochloride. eHealthMe is studying from 115 Protriptyline hydrochloride users. Check the latest studies of Protriptyline hydrochloride.

What is Aspirin?

Aspirin has active ingredients of aspirin. It is often used in blood clots. eHealthMe is studying from 632,088 Aspirin users. Check the latest studies of Aspirin.



On Jul, 14, 2026

14 people who take Protriptyline hydrochloride and Aspirin together, and have interactions are studied.

Protriptyline hydrochloride and Aspirin drug interactions.

What are the common drug interactions of Protriptyline Hydrochloride and Aspirin, by gender? *:

female:

  1. Fall
  2. Somnolence (a state of near-sleep, a strong desire for sleep)
  3. Angina pectoris (chest pain due to ischemia of the heart muscle)
  4. Bradyphrenia (neurological term referring to the slowness of thought common to many disorders of the brain)
  5. Chronic kidney disease
  6. Epistaxis (bleed from the nose)
  7. Face injury
  8. Hypoaesthesia (reduced sense of touch or sensation)
  9. Injury
  10. Pain in extremity

male:

  1. Cough
  2. Disorientation (disability in which the senses of time, direction, and recognition of people and places)
  3. Vertigo
  4. Weight increased
  5. Dyskinesia (abnormality or impairment of voluntary movement)
  6. Fall
  7. Hypoglycaemia (deficiency of glucose in the bloodstream)
  8. Incontinence (lack of moderation or self-control)
  9. Nocturia (the need to get up in the night to urinate)
  10. Osteoarthritis (a joint disease caused by cartilage loss in a joint)

What are the common drug interactions of Protriptyline Hydrochloride and Aspirin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

  1. Balance disorder
  2. Migraine (headache)
  3. Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
  4. Sleep-related eating disorder (abnormal eating patterns during the night)
  5. Somnambulism (sleep walking)
  6. Weight increased

30-39:

n/a

40-49:

  1. Vertigo
  2. Weight increased

50-59:

  1. Hypoglycaemia (deficiency of glucose in the bloodstream)
  2. Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))

60+:

  1. Fall
  2. Somnolence (a state of near-sleep, a strong desire for sleep)
  3. Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
  4. Urinary tract infection
  5. Arthritis (form of joint disorder that involves inflammation of one or more joints)
  6. Contusion (a type of hematoma of tissue in which capillaries)
  7. Cough
  8. Depression
  9. Disorientation (disability in which the senses of time, direction, and recognition of people and places)
  10. Dyskinesia (abnormality or impairment of voluntary movement)

What are the existing conditions these people have? *

  1. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 12 people, 85.71%
  2. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 11 people, 78.57%
  3. Drowsiness: 2 people, 14.29%
  4. Urinary Tract Infection: 1 person, 7.14%
  5. Stable Angina (a constant chest pain): 1 person, 7.14%
  6. Proctalgia (pain in the rectum): 1 person, 7.14%
  7. Pelvic Pain: 1 person, 7.14%
  8. Pain: 1 person, 7.14%
  9. Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 1 person, 7.14%
  10. Gastric Disorder (disease of stomach): 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

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Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Protriptyline hydrochloride and Aspirin:

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Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Protriptyline hydrochloride:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Aspirin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Protriptyline hydrochloride and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Aspirin and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on protriptyline hydrochloride and aspirin (the active ingredients of Protriptyline hydrochloride and Aspirin, respectively), and Protriptyline hydrochloride and Aspirin (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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