Requip xl and Simvastatin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Requip xl (ropinirole hydrochloride) and Simvastatin (simvastatin). Common drug interactions include movement disorder among females and somnolence among males.

The phase IV clinical study analyzes what interactions people have when they take Requip xl and Simvastatin. It is created by eHealthMe based on reports of 51 people who take the same drugs from the FDA, and is updated regularly.

What is Requip xl?

Requip xl has active ingredients of ropinirole hydrochloride. It is often used in parkinson's disease. eHealthMe is studying from 1,297 Requip xl users. Check the latest studies of Requip xl.

What is Simvastatin?

Simvastatin has active ingredients of simvastatin. It is often used in high blood cholesterol. eHealthMe is studying from 256,970 Simvastatin users. Check the latest studies of Simvastatin.

On Aug, 04, 2026

51 people who take Requip xl and Simvastatin together, and have interactions are studied.

Requip xl and Simvastatin drug interactions.

What are the common drug interactions of Requip Xl and Simvastatin, by gender? *:

female:

Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness)
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Neck pain
Pain
Peripheral embolism (sudden interruption of blood flow to an organ or body part)
Peripheral swelling
Pulmonary embolism (blockage of the main artery of the lung)
Rash
Sedation
Skin discolouration (change of skin colour)

male:

Somnolence (a state of near-sleep, a strong desire for sleep)
Hallucination (an experience involving the perception of something not present)
Tremor (trembling or shaking movements in one or more parts of your body)
Balance disorder
Hyperhidrosis (abnormally increased sweating)
Laziness
Abnormal behaviour
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Feeling hot
Migraine (headache)

What are the common drug interactions of Requip Xl and Simvastatin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Fatigue (feeling of tiredness)
Laziness
Abnormal behaviour
Hallucination (an experience involving the perception of something not present)
Somnolence (a state of near-sleep, a strong desire for sleep)
Arthralgia (joint pain)
Blood glucose increased
Dyspepsia (indigestion)
Fall
Headache (pain in head)

60+:

Somnolence (a state of near-sleep, a strong desire for sleep)
Rash
Nausea (feeling of having an urge to vomit)
Tremor (trembling or shaking movements in one or more parts of your body)
Dizziness
Drug ineffective
Drug intolerance (drug sensitivity)
Hallucination (an experience involving the perception of something not present)
Hyperhidrosis (abnormally increased sweating)
Middle insomnia (difficulty returning to sleep after awakening either in the middle of the night)

What are the existing conditions these people have? *

Restless Leg Syndrome (a powerful urge to move your legs): 14 people, 27.45%
Hallucinations (sensations that appear real but are created by your mind): 8 people, 15.69%
Psychotic Disorder: 7 people, 13.73%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 7 people, 13.73%
Delusion (a false belief or opinion): 6 people, 11.76%
Tremor (trembling or shaking movements in one or more parts of your body): 3 people, 5.88%
Psychotic Disorder Due To A General Medical Condition: 3 people, 5.88%

* Approximation only. Some reports may have incomplete information.

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