Septra and Macrobid drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Septra (sulfamethoxazole; trimethoprim) and Macrobid (nitrofurantoin; nitrofurantoin, macrocrystalline). Common drug interactions include pulmonary embolism among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Septra and Macrobid. It is created by eHealthMe based on reports of 63 people who take the same drugs from the FDA, and is updated regularly.

What is Septra?

Septra has active ingredients of sulfamethoxazole; trimethoprim. It is often used in urinary tract infection. eHealthMe is studying from 10,280 Septra users. Check the latest studies of Septra.

What is Macrobid?

Macrobid has active ingredients of nitrofurantoin; nitrofurantoin, macrocrystalline. It is often used in urinary tract infection. eHealthMe is studying from 9,215 Macrobid users. Check the latest studies of Macrobid.

On Jul, 19, 2026

63 people who take Septra and Macrobid together, and have interactions are studied.

What are the common drug interactions of Septra and Macrobid, by gender? *:

female:

Pulmonary embolism (blockage of the main artery of the lung)
Chest pain
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dizziness
Oedema peripheral (superficial swelling)
Anxiety
Breast mass
Cardiomegaly (increased size of heart than normal)
Cystitis haemorrhagic (blood in the urine and painful voiding)
Injury

male:

Anxiety
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Pallor
Post-operative wound infection
Activities of daily living impaired
Angina pectoris (chest pain due to ischemia of the heart muscle)
Arrhythmia (irregular heartbeat)
Asthenia (weakness)
Balance disorder
Cellulitis (infection under the skin)

What are the common drug interactions of Septra and Macrobid, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abdominal pain
Abdominal pain lower
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Breast mass
Chest pain
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Depression
Device dislocation
Dyspepsia (indigestion)

30-39:

Abortion induced (medically referred abortion)
Amenorrhoea (absence of a menstrual period in a woman of reproductive age)
Cervicitis (inflammation of the uterine cervix)
Ectopic pregnancy (a pregnancy in which the foetus develops outside the uterus, typically in a fallopian tube)
Haemoperitoneum (presence of blood in the peritoneal cavity)
Haemorrhage (bleeding)
Hyperuricaemia (level of uric acid in the blood that is abnormally high)
Intertrigo (inflammation (rash) of the body folds (adjacent areas of skin))
Menstruation irregular
Obesity (having too much body fat)

40-49:

Nausea (feeling of having an urge to vomit)
Pulmonary embolism (blockage of the main artery of the lung)
Breast mass
Chest pain
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dyspnoea (difficult or laboured respiration)
Oedema peripheral (superficial swelling)
Pain in extremity
Drug hypersensitivity
Abasia (inability to walk)

50-59:

Blood pressure decreased
Cough
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Depressed mood
Diarrhoea
Drug hypersensitivity
Drug ineffective
Dry eye (lack of adequate tears)
Faeces pale
Fatigue (feeling of tiredness)

60+:

Drug hypersensitivity
Pain
Inflammation
C-reactive protein increased
Cardiac disorder
Chest injury
Death
Decreased appetite
Fluid retention (an abnormal accumulation of fluid in the blood)
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 10 people, 15.87%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 10 people, 15.87%
Cardiac Disorder: 10 people, 15.87%
Transient Ischaemic Attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow)): 8 people, 12.70%
Pain: 5 people, 7.94%
Thyroid Diseases: 4 people, 6.35%
Multiple Myeloma (cancer of the plasma cells): 4 people, 6.35%
Genital Haemorrhage (bleeding from genital): 4 people, 6.35%

* Approximation only. Some reports may have incomplete information.

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