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A study for a 77 year old woman who takes Methotrexate Sodium, Folic Acid, Synthroid, Atorvastatin Calcium (an AI-powered real world drug study)

Summary:

1,831 females aged 77 (±5) who take the same drugs and have adverse effects are studied. This is a phase IV clinical study for a 77 year old female patient who has High Cholesterol, Partial Thyroidectomy, Rheumatoid Arthritis. The study is created by eHealthMe based on reports from sources including the FDA.


On Jul, 30, 2026

1,831 females aged 77 (±5) who take Methotrexate Sodium, Folic Acid, Synthroid, Atorvastatin Calcium and have adverse effects are studied.


Number of reports submitted per year:

Methotrexate Sodium, Folic Acid, Synthroid, Atorvastatin Calcium for a 77-year old woman.

Information of the patient in this study:

  • Age: 77
  • Gender: female

What are the drugs?

What are the conditions?

What are the adverse effects?


Comparison with patient's specific adverse outcomes:

You can check what is more associated with an adverse outcome: a drug mix, a drug, a condition, or a population of certain gender and age. Each patient is different. It is not uncommon that the results can be inconclusive or insignificant.

By the same drug(s):

  • Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints):
    - among females aged 77 (±5) who take the same drugs: 0.38% (7 of 1,831)
    - among people who take the same drugs, regardless of gender or age: 0.04% (7 of 16,865)

By each condition:

  • people who have Rheumatoid Arthritis with High Cholesterol:
    - among females aged 77 (±5) who have High Cholesterol: 0.53% (222 of 41,692)
    - among people who have High Cholesterol, regardless of gender or age: 0.51% (1,831 of 360,958)
  • people who have Rheumatoid Arthritis with Partial Thyroidectomy:
    - among females aged 77 (±5) who have Partial Thyroidectomy: 0.94% (7 of 748)
    - among people who have Partial Thyroidectomy, regardless of gender or age: 0.62% (41 of 6,597)

By each drug (FDA data only):

  • people who take Atorvastatin Calcium and have Rheumatoid Arthritis:
    - among females aged 77 (±5) who take Atorvastatin Calcium and have side effects: 0.47% (32 of 6,772)
    - among people who take Atorvastatin Calcium and have side effects, regardless of gender or age: 0.83% (602 of 72,761)
  • people who take Folic Acid and have Rheumatoid Arthritis:
    - among females aged 77 (±5) who take Folic Acid and have side effects: 3.4% (392 of 11,543)
    - among people who take Folic Acid and have side effects, regardless of gender or age: 6.78% (11,012 of 162,499)
  • people who take Synthroid and have Rheumatoid Arthritis:
    - among females aged 77 (±5) who take Synthroid and have side effects: 1.04% (296 of 28,535)
    - among people who take Synthroid and have side effects, regardless of gender or age: 1.58% (3,748 of 237,813)
  • people who take Methotrexate Sodium and have Rheumatoid Arthritis:
    - among females aged 77 (±5) who take Methotrexate Sodium and have side effects: 6.69% (544 of 8,136)
    - among people who take Methotrexate Sodium and have side effects, regardless of gender or age: 10.18% (9,807 of 96,379)

Common drug interactions *:

  1. Drug Ineffective : 176 people, 9.61%
  2. Pain : 172 people, 9.39%
  3. Pneumonia : 155 people, 8.47%
  4. Fall : 151 people, 8.25%
  5. Fatigue (feeling of tiredness): 134 people, 7.32%
  6. Joint Pain : 133 people, 7.26%
  7. Weakness : 119 people, 6.50%
  8. Nausea (feeling of having an urge to vomit): 113 people, 6.17%
  9. Pain In Extremity : 105 people, 5.73%
  10. Dyspnea (difficult or laboured breathing): 100 people, 5.46%
  11. Diarrhea : 93 people, 5.08%
  12. Rashes (redness): 92 people, 5.02%
  13. Weight Decreased : 89 people, 4.86%
  14. Joint Swelling : 82 people, 4.48%
  15. Abdominal Pain : 76 people, 4.15%
  16. Dizziness : 75 people, 4.10%
  17. Urinary Tract Infection : 75 people, 4.10%
  18. Back Pain : 74 people, 4.04%
  19. Nausea And Vomiting : 72 people, 3.93%
  20. Gait Disturbance : 72 people, 3.93%

Common co-existing conditions *:

You may use this to check any potential undetected conditions.

  1. Pain : 124 people, 6.77%
  2. Osteoporosis (bones weak and more likely to break): 101 people, 5.52%
  3. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 75 people, 4.10%
  4. Diabetes : 61 people, 3.33%
  5. Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 55 people, 3.00%
  6. Depression : 47 people, 2.57%
  7. Stress And Anxiety : 42 people, 2.29%
  8. Insomnia (sleeplessness): 37 people, 2.02%
  9. Hyperlipidaemia (presence of excess lipids in the blood): 37 people, 2.02%
  10. Asthma : 35 people, 1.91%
  11. Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 32 people, 1.75%
  12. Hypersensitivity : 32 people, 1.75%
  13. Anaemia (lack of blood): 31 people, 1.69%
  14. Cardiac Disorder : 30 people, 1.64%
  15. Psoriasis (immune-mediated disease that affects the skin): 28 people, 1.53%
  16. Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 27 people, 1.47%
  17. Type 2 Diabetes : 27 people, 1.47%
  18. Blood Pressure Abnormal : 22 people, 1.20%
  19. Fluid Retention (an abnormal accumulation of fluid in the blood): 22 people, 1.20%
  20. Urinary Tract Infection : 22 people, 1.20%

Common co-used drugs *:

You may use this to check any potential interacting drugs.

  1. Prednisone (397 people, 21.68%)
  2. Humira (391 people, 21.35%)
  3. Aspirin (324 people, 17.70%)
  4. Enbrel (222 people, 12.12%)
  5. Tylenol (201 people, 10.98%)
  6. Acetaminophen (178 people, 9.72%)
  7. Furosemide (165 people, 9.01%)
  8. Calcium (165 people, 9.01%)
  9. Omeprazole (157 people, 8.57%)
  10. Remicade (146 people, 7.97%)
  11. Pantoprazole (143 people, 7.81%)
  12. Amlodipine (143 people, 7.81%)
  13. Hydrochlorothiazide (139 people, 7.59%)
  14. Orencia (130 people, 7.10%)
  15. Gabapentin (119 people, 6.50%)
  16. Celebrex (111 people, 6.06%)
  17. Lisinopril (111 people, 6.06%)
  18. Vitamin D3 (104 people, 5.68%)
  19. Metformin (103 people, 5.63%)
  20. Plaquenil (101 people, 5.52%)

Drug effectiveness *:

Methotrexate Sodium:

n/a

Folic Acid:

n/a

Synthroid:

n/a

Atorvastatin Calcium:

n/a

* Some reports may have incomplete information.


How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Related studies

Drug side effects in long term, by gender and age:

Treatments, associated medications and conditions:

Drug side effects:

Drug interactions:

Drugs that are associated with:

Conditions that are associated with:

How the phase IV clinical study uses the data?

The study is based on gender, age, active ingredients of any drugs used. Other drugs that have the same active ingredients (e.g. generic drugs) are considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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