Excedrin and Itching - a phase IV clinical study of FDA data

Summary:

Itching is reported as a side effect among people who take Excedrin (acetaminophen; aspirin; caffeine), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Vitamin D3, and have Multiple sclerosis.

The phase IV clinical study analyzes which people have Itching when taking Excedrin. It is created by eHealthMe based on reports of 21,620 people who have side effects when taking Excedrin from the FDA, and is updated regularly.

What is Excedrin?

Excedrin has active ingredients of acetaminophen; aspirin; caffeine. It is often used in headache. eHealthMe is studying from 22,739 Excedrin users. Check the latest studies of Excedrin.

What is Itching?

Itching is found to be associated with 3,223 drugs and 4,506 conditions by eHealthMe. Check the latest studies of Itching.

On Dec, 06, 2025

21,620 people reported to have side effects when taking Excedrin.
Among them, 338 people (1.56%) have Itching.

Among these 338 people:

* Approximation only. Some reports may have incomplete information.

Do you take Excedrin and have Itching?

- Check whether Itching is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Excedrin:

Excedrin (22,739 reports)

Itching treatments and more:

Itching (398,805 reports)

How severe was Itching and when was it recovered:

Itching in Excedrin

Expand to all the drugs that have ingredients of acetaminophen; aspirin; caffeine:

Itching and drugs with ingredients of acetaminophen; aspirin; caffeine (332 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Common Excedrin side effects:

Excedrin side effect: Drug ineffective (4,663 reports)
Excedrin side effect: Nausea (feeling of having an urge to vomit) (1,550 reports)

Browse all side effects of Excedrin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common drugs associated with Itching:

Browse all the drugs that are associated with Itching:

Itching (3,223 drugs)

Common conditions associated with Itching:

Rheumatoid arthritis: 20,749 reports
Psoriasis: 19,506 reports
Dermatitis atopic: 18,622 reports
Ms hug: 13,880 reports
Hypertension: 13,304 reports
Blood pressure increased: 13,217 reports
Blood pressure - high: 13,212 reports
Hypercholesterolemia: 10,654 reports
Pain: 8,403 reports
Alternative medicine - pain relief: 8,336 reports

Browse all the conditions that are associated with Itching:

Itching (4,506 conditions)

Drugs similar to Excedrin and Itching :

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen; aspirin; caffeine (the active ingredients of Excedrin) and Excedrin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.