Lortab and Hypercoagulation - a phase IV clinical study of FDA data

Summary:

Hypercoagulation is reported as a side effect among people who take Lortab (acetaminophen; hydrocodone bitartrate), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Ambien, and have Metastases to bone.

The phase IV clinical study analyzes which people have Hypercoagulation when taking Lortab. It is created by eHealthMe based on reports of 29,547 people who have side effects when taking Lortab from the FDA, and is updated regularly.

What is Lortab?

Lortab has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. eHealthMe is studying from 31,285 Lortab users. Check the latest studies of Lortab.

What is Hypercoagulation?

Hypercoagulation (increased tendency for clotting of the blood) is found to be associated with 428 drugs and 533 conditions by eHealthMe. Check the latest studies of Hypercoagulation.

On Dec, 26, 2025

29,547 people reported to have side effects when taking Lortab.
Among them, 47 people (0.16%) have Hypercoagulation.

Among these 47 people:

How long have people been on Lortab when they have Hypercoagulation? *

What is the gender of people who have Hypercoagulation when taking Lortab? *

female: 93.18 %
male: 6.82 %

What is the age of people who have Hypercoagulation when taking Lortab? *

What are other drugs people take besides Lortab? *

What are other side effects people have besides Hypercoagulation? *

Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 42 people, 89.36%
Chest Pain: 30 people, 63.83%
Weight Decreased: 28 people, 59.57%
Joint Pain: 27 people, 57.45%
Headache (pain in head): 27 people, 57.45%
Dyspnea (difficult or laboured breathing): 27 people, 57.45%
Rectal Haemorrhage (bleeding from anus): 25 people, 53.19%
Fatigue (feeling of tiredness): 24 people, 51.06%
Metastases To Bone (cancer spreads to bone): 23 people, 48.94%
Osteosclerosis (an elevation in bone density): 23 people, 48.94%

What are the existing conditions these people have? *

Metastases To Bone (cancer spreads to bone): 21 people, 44.68%
Birth Control: 6 people, 12.77%
Headache (pain in head): 4 people, 8.51%
Migraine (headache): 3 people, 6.38%
Bone Loss: 3 people, 6.38%
Endometriosis (appearance of endometrial tissue outside the uterus and causing pelvic pain): 3 people, 6.38%
Osteoporosis (bones weak and more likely to break): 3 people, 6.38%
Chronic Myeloid Leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood): 2 people, 4.26%
Weight Decreased: 2 people, 4.26%
Nausea (feeling of having an urge to vomit): 1 person, 2.13%

* Approximation only. Some reports may have incomplete information.

Do you take Lortab and have Hypercoagulation?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Lortab:

Lortab (31,285 reports)

Hypercoagulation treatments and more:

Hypercoagulation (4,011 reports)

How severe was Hypercoagulation and when was it recovered:

Hypercoagulation in Lortab

Expand to all the drugs that have ingredients of acetaminophen; hydrocodone bitartrate:

Hypercoagulation and drugs with ingredients of acetaminophen; hydrocodone bitartrate (123 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Lortab:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hypercoagulation:

Hypercoagulation (428 drugs)

Browse all the conditions that are associated with Hypercoagulation:

Hypercoagulation (533 conditions)

Drugs similar to Lortab and Hypercoagulation :

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen; hydrocodone bitartrate (the active ingredients of Lortab) and Lortab (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.