Lotrel and Sinus node dysfunction - a phase IV clinical study of FDA data

Summary:

Sinus node dysfunction is reported as a side effect among people who take Lotrel (amlodipine besylate; benazepril hydrochloride), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Toprol-Xl, and have Constipation.

The phase IV clinical study analyzes which people have Sinus node dysfunction when taking Lotrel. It is created by eHealthMe based on reports of 13,000 people who have side effects when taking Lotrel from the FDA, and is updated regularly.

What is Lotrel?

Lotrel has active ingredients of amlodipine besylate; benazepril hydrochloride. It is often used in high blood pressure. eHealthMe is studying from 13,569 Lotrel users. Check the latest studies of Lotrel.

What is Sinus node dysfunction?

Sinus node dysfunction (a group of abnormal heart rhythms) is found to be associated with 1,179 drugs and 840 conditions by eHealthMe. Check the latest studies of Sinus node dysfunction.

On Jan, 26, 2026

13,000 people reported to have side effects when taking Lotrel.
Among them, 46 people (0.35%) have Sinus node dysfunction.

Could Lotrel cause Sinus node dysfunction?

Among these 46 people:

How long have people been on Lotrel when they have Sinus node dysfunction? *

What is the gender of people who have Sinus node dysfunction when taking Lotrel? *

female: 20 %
male: 80 %

What is the age of people who have Sinus node dysfunction when taking Lotrel? *

What are other drugs people take besides Lotrel? *

What are other side effects people have besides Sinus node dysfunction? *

Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 38 people, 82.61%
Stress And Anxiety: 26 people, 56.52%
Fatigue (feeling of tiredness): 26 people, 56.52%
Pain: 23 people, 50.00%
Anhedonia (inability to experience pleasure from activities usually found enjoyable): 23 people, 50.00%
Injury: 23 people, 50.00%
Nausea (feeling of having an urge to vomit): 22 people, 47.83%
Nausea And Vomiting: 22 people, 47.83%
Fall: 21 people, 45.65%
Diarrhea: 21 people, 45.65%

What are the existing conditions these people have? *

Constipation: 11 people, 23.91%
Diabetes: 5 people, 10.87%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 4 people, 8.70%
Type 2 Diabetes: 3 people, 6.52%
Pain: 2 people, 4.35%
Multiple Myeloma (cancer of the plasma cells): 1 person, 2.17%
Heart Rate Increased: 1 person, 2.17%
Gastrointestinal Stromal Tumor: 1 person, 2.17%
Coronary Heart Disease (narrowing or blockage of the coronary arteries): 1 person, 2.17%

* Approximation only. Some reports may have incomplete information.

Do you take Lotrel and have Sinus node dysfunction?

- Check whether Sinus node dysfunction is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Lotrel:

Lotrel (13,569 reports)

Sinus node dysfunction treatments and more:

Sinus node dysfunction (4,617 reports)

How severe was Sinus node dysfunction and when was it recovered:

Sinus node dysfunction in Lotrel

Expand to all the drugs that have ingredients of amlodipine besylate; benazepril hydrochloride:

Sinus node dysfunction and drugs with ingredients of amlodipine besylate; benazepril hydrochloride

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Lotrel:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Sinus node dysfunction:

Sinus node dysfunction (1,179 drugs)

Browse all the conditions that are associated with Sinus node dysfunction:

Sinus node dysfunction (840 conditions)

Drugs similar to Lotrel and Sinus node dysfunction :

How the study uses the data?

The study uses data from the FDA. It is based on amlodipine besylate; benazepril hydrochloride (the active ingredients of Lotrel) and Lotrel (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.