Toprol-xl and Sinus node dysfunction - a phase IV clinical study of FDA data
Summary:
Sinus node dysfunction is reported as a side effect among people who take Toprol-xl (metoprolol succinate), especially for people who are female, 60+ old, also take Ambien, and have Pain.
The phase IV clinical study analyzes which people have Sinus node dysfunction when taking Toprol-xl. It is created by eHealthMe based on reports of 38,273 people who have side effects when taking Toprol-xl from the FDA, and is updated regularly.
What is Toprol-xl?
Toprol-xl has active ingredients of metoprolol succinate. It is often used in high blood pressure. eHealthMe is studying from 40,634 Toprol-xl users. Check the latest studies of Toprol-xl.
What is Sinus node dysfunction?
Sinus node dysfunction (a group of abnormal heart rhythms) is found to be associated with 1,178 drugs and 840 conditions by eHealthMe. Check the latest studies of Sinus node dysfunction.
38,273 people reported to have side effects when taking Toprol-xl.
Among them, 102 people (0.27%) have Sinus node dysfunction.

Among these 102 people:
What is the gender of people who have Sinus node dysfunction when taking Toprol-xl? *
What is the age of people who have Sinus node dysfunction when taking Toprol-xl? *
What are other drugs people take besides Toprol-xl? *
What are other side effects people have besides Sinus node dysfunction? *
What are the existing conditions these people have? *
* Approximation only. Some reports may have incomplete information.
Do you take Toprol-xl and have Sinus node dysfunction?
- Check whether Sinus node dysfunction is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
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Related studies:
Effectiveness of, long term effects of, and alternative drugs to Toprol-xl:
- Toprol-xl (40,634 reports)
Sinus node dysfunction treatments and more:
- Sinus node dysfunction (4,617 reports)
How severe was Sinus node dysfunction and when was it recovered:
Expand to all the drugs that have ingredients of metoprolol succinate:
Sub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Common Toprol-xl side effects:
- Toprol-xl side effect: Dyspnea (difficult or laboured breathing) (2,923 reports)
- Toprol-xl side effect: Heart attack (2,470 reports)
- Toprol-xl side effect: Drug ineffective (2,012 reports)
- Toprol-xl side effect: Cardiac failure congestive (1,729 reports)
- Toprol-xl side effect: Fall (1,664 reports)
- Toprol-xl side effect: Nausea and vomiting (1,661 reports)
- Toprol-xl side effect: Oedema peripheral (superficial swelling) (1,613 reports)
- Toprol-xl side effect: Atrial fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles) (1,510 reports)
- Toprol-xl side effect: Pain in extremity (1,496 reports)
- Toprol-xl side effect: Anaemia (lack of blood) (1,479 reports)
- Toprol-xl side effect: Stroke (sudden death of a portion of the brain cells due to a lack of oxygen) (1,464 reports)
- Toprol-xl side effect: Malaise (a feeling of general discomfort or uneasiness) (1,356 reports)
- Toprol-xl side effect: Injury (1,339 reports)
- Toprol-xl side effect: Coronary heart disease (narrowing or blockage of the coronary arteries) (1,191 reports)
- Toprol-xl side effect: Constipation (1,098 reports)
- Toprol-xl side effect: Blood glucose increased (1,093 reports)
- Toprol-xl side effect: Dehydration (dryness resulting from the removal of water) (1,039 reports)
- Toprol-xl side effect: Urinary tract infection (967 reports)
- Toprol-xl side effect: Itching (935 reports)
- Toprol-xl side effect: Cardiac disorder (912 reports)
- Toprol-xl side effect: Hypoaesthesia (reduced sense of touch or sensation) (902 reports)
- Toprol-xl side effect: Abdominal pain upper (868 reports)
- Toprol-xl side effect: Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect) (833 reports)
- Toprol-xl side effect: Vision blurred (811 reports)
- Toprol-xl side effect: Confusional state (785 reports)
- Toprol-xl side effect: Emotional distress (769 reports)
- Toprol-xl side effect: Muscle spasms (muscle contraction) (764 reports)
- Toprol-xl side effect: Gait disturbance (715 reports)
- Toprol-xl side effect: Tremor (trembling or shaking movements in one or more parts of your body) (709 reports)
- Toprol-xl side effect: Condition (688 reports)
- Toprol-xl side effect: Head injury (667 reports)
- Toprol-xl side effect: Loss of consciousness (616 reports)
- Toprol-xl side effect: Anhedonia (inability to experience pleasure from activities usually found enjoyable) (598 reports)
- Toprol-xl side effect: Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow)) (582 reports)
- Toprol-xl side effect: Haemoglobin decreased (581 reports)
- Toprol-xl side effect: Fear (547 reports)
- Toprol-xl side effect: Mitral valve incompetence (inefficient heart valve) (525 reports)
- Toprol-xl side effect: Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe) (522 reports)
- Toprol-xl side effect: Renal impairment (severely reduced kidney function) (521 reports)
- Toprol-xl side effect: Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body) (520 reports)
- Toprol-xl side effect: Blood creatinine increased (494 reports)
- Toprol-xl side effect: Bone disorder (491 reports)
- Toprol-xl side effect: Gastrointestinal haemorrhage (bleeding gastrointestinal tract) (476 reports)
- Toprol-xl side effect: Chills (felling of cold) (474 reports)
- Toprol-xl side effect: Abdominal distension (469 reports)
- Toprol-xl side effect: Hypersensitivity (461 reports)
- Toprol-xl side effect: Pulmonary embolism (blockage of the main artery of the lung) (458 reports)
- Toprol-xl side effect: Dry mouth (446 reports)
- Toprol-xl side effect: Abdominal discomfort (438 reports)
- Toprol-xl side effect: Acute myocardial infarction (acute heart attack) (433 reports)
- Toprol-xl side effect: Nervousness (428 reports)
- Toprol-xl side effect: Cataract (clouding of the lens inside the eye) (425 reports)
- Toprol-xl side effect: Gastric ulcer (stomach ulcer) (424 reports)
- Toprol-xl side effect: International normalised ratio increased (419 reports)
- Toprol-xl side effect: Respiratory acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease) (413 reports)
- Toprol-xl side effect: Hyperlipidaemia (presence of excess lipids in the blood) (411 reports)
- Toprol-xl side effect: Spinal osteoarthritis (joint cartilage loss in spine) (407 reports)
- Toprol-xl side effect: Coronary artery occlusion (complete obstruction of blood flow in a coronary artery) (399 reports)
- Toprol-xl side effect: Cellulitis (infection under the skin) (395 reports)
- Toprol-xl side effect: Oedema (fluid collection in tissue) (384 reports)
- Toprol-xl side effect: Osteomyelitis (infection of bone) (376 reports)
- Toprol-xl side effect: Swelling (375 reports)
- Toprol-xl side effect: Asthma (366 reports)
- Toprol-xl side effect: Renal injury (kidney injury) (363 reports)
- Toprol-xl side effect: Osteoporosis (bones weak and more likely to break) (360 reports)
- Toprol-xl side effect: Heart rate decreased (358 reports)
- Toprol-xl side effect: Tricuspid valve incompetence (inefficient heart valve) (357 reports)
- Toprol-xl side effect: Speech impairment (adult) (inability to speak (adult)) (355 reports)
- Toprol-xl side effect: Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves) (352 reports)
- Toprol-xl side effect: Visual impairment (349 reports)
- Toprol-xl side effect: Infection (346 reports)
- Toprol-xl side effect: Agitation (state of anxiety or nervous excitement) (345 reports)
- Toprol-xl side effect: Gastritis (inflammation of stomach) (344 reports)
- Toprol-xl side effect: Blood urea increased (339 reports)
- Toprol-xl side effect: Upper respiratory tract infection (338 reports)
- Toprol-xl side effect: Thrombosis (formation of a blood clot inside a blood vessel) (336 reports)
- Toprol-xl side effect: Cardiomyopathy (weakening of the heart muscle) (335 reports)
- Toprol-xl side effect: Drug hypersensitivity (334 reports)
- Toprol-xl side effect: Balance disorder (333 reports)
- Toprol-xl side effect: Aseptic necrosis (the death of bone tissue due to a lack of blood supply) (331 reports)
- Toprol-xl side effect: Multi-organ failure (multisystem organ failure) (329 reports)
- Toprol-xl side effect: Adverse event (327 reports)
- Toprol-xl side effect: Blood glucose decreased (326 reports)
- Toprol-xl side effect: Nasopharyngitis (inflammation of the nasopharynx) (318 reports)
- Toprol-xl side effect: Influenza like illness (317 reports)
- Toprol-xl side effect: Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down) (316 reports)
- Toprol-xl side effect: Pulmonary oedema (fluid accumulation in the lungs) (314 reports)
- Toprol-xl side effect: Burning sensation (310 reports)
- Toprol-xl side effect: Aspartate aminotransferase increased (307 reports)
- Toprol-xl side effect: Intervertebral disc degeneration (spinal disc degeneration) (306 reports)
- Toprol-xl side effect: Tinnitus (a ringing in the ears) (305 reports)
- Toprol-xl side effect: Pulmonary hypertension (increase in blood pressure in the lung artery) (303 reports)
- Toprol-xl side effect: Ill-defined disorder (299 reports)
- Toprol-xl side effect: Visual acuity reduced (reduced clearness of vision) (298 reports)
- Toprol-xl side effect: Urination - painful (297 reports)
- Toprol-xl side effect: Osteopenia (a condition where bone mineral density is lower than normal) (293 reports)
- Toprol-xl side effect: Multiple injuries (290 reports)
- Toprol-xl side effect: Erection problems (284 reports)
- Toprol-xl side effect: Abasia (inability to walk) (282 reports)
- Toprol-xl side effect: Hallucinations (sensations that appear real but are created by your mind) (281 reports)
- Toprol-xl side effect: Haemorrhoids (a swollen vein or group of veins in the region of the anus) (279 reports)
- Toprol-xl side effect: Haematocrit decreased (274 reports)
- Toprol-xl side effect: Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves) (271 reports)
- Toprol-xl side effect: Angina unstable (chest pain due to ischemia of the heart muscle- unstable) (265 reports)
- Toprol-xl side effect: Impaired healing (260 reports)
- Toprol-xl side effect: Abnormal dreams (258 reports)
- Toprol-xl side effect: Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body) (257 reports)
- Toprol-xl side effect: Hoarseness or changing voice (255 reports)
- Toprol-xl side effect: Neoplasm malignant (cancer tumour) (254 reports)
- Toprol-xl side effect: White blood cell count decreased (253 reports)
- Toprol-xl side effect: Dental caries (246 reports)
- Toprol-xl side effect: Ventricular tachycardia (rapid heartbeat that originates in one of the lower chambers (the ventricles) of the heart) (239 reports)
- Toprol-xl side effect: Tooth abscess (pus formation in tooth) (236 reports)
- Toprol-xl side effect: Cardiac murmur (an heart sound in valve abnormality) (235 reports)
- Toprol-xl side effect: Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease) (231 reports)
- Toprol-xl side effect: Ejection fraction decreased (systolic heart failure) (230 reports)
- Toprol-xl side effect: Speech disorder (229 reports)
- Toprol-xl side effect: Blood potassium decreased (227 reports)
- Toprol-xl side effect: Injection site pain (226 reports)
- Toprol-xl side effect: Haematochezia (passage of stools containing blood) (223 reports)
- Toprol-xl side effect: Disturbance in attention (219 reports)
- Toprol-xl side effect: Swelling face (218 reports)
- Toprol-xl side effect: Rib fracture (207 reports)
- Toprol-xl side effect: Hepatic steatosis (fatty liver disease) (205 reports)
- Toprol-xl side effect: Blood creatine phosphokinase increased (202 reports)
- Toprol-xl side effect: Aortic valve incompetence (200 reports)
- Toprol-xl side effect: Ventricular hypertrophy (enlargement of ventricles (lower chambers) in the heart) (199 reports)
- Toprol-xl side effect: Decreased interest (197 reports)
- Toprol-xl side effect: Disease progression (195 reports)
- Toprol-xl side effect: Staphylococcal infection (an infection with staphylococcus bacteria) (194 reports)
- Toprol-xl side effect: Respiratory distress (difficulty in breathing) (193 reports)
- Toprol-xl side effect: Heart disease (192 reports)
- Toprol-xl side effect: Cardio-respiratory arrest (sudden dysfunction of heart and lungs) (191 reports)
- Toprol-xl side effect: Haematoma (collection of blood outside the blood vessels) (184 reports)
- Toprol-xl side effect: White blood cell count increased (182 reports)
- Toprol-xl side effect: Hip fracture (181 reports)
- Toprol-xl side effect: Lung infiltration (a substance that normally includes fluid, inflammatory exudates or cells that fill a region of lung) (178 reports)
- Toprol-xl side effect: Mood swings (an extreme or rapid change in mood) (177 reports)
- Toprol-xl side effect: Unresponsive to stimuli (176 reports)
- Toprol-xl side effect: Therapeutic agent toxicity (poisoning by ability to cure substance) (175 reports)
- Toprol-xl side effect: Difficulty in walking (174 reports)
- Toprol-xl side effect: Diabetes mellitus inadequate control (172 reports)
- Toprol-xl side effect: Stomatitis (inflammation of mucous membrane of mouth) (171 reports)
- Toprol-xl side effect: Gastrointestinal disorder (functional problems of gastrointestinal tract) (168 reports)
- Toprol-xl side effect: Spinal compression fracture (fracture due to spinal compression on bone) (167 reports)
- Toprol-xl side effect: Tooth disorder (tooth disease) (166 reports)
- Toprol-xl side effect: Rotator cuff syndrome (a spectrum of conditions affecting the rotator cuff tendons of the shoulder) (165 reports)
- Toprol-xl side effect: Presyncope (164 reports)
- Toprol-xl side effect: Hepatic enzyme increased (163 reports)
- Toprol-xl side effect: Pulmonary congestion (congestion in the lungs) (162 reports)
- Toprol-xl side effect: Tooth loss (161 reports)
- Toprol-xl side effect: Skin ulcer (157 reports)
- Toprol-xl side effect: Metastases to bone (cancer spreads to bone) (154 reports)
- Toprol-xl side effect: Night sweats (sweating in night) (150 reports)
- Toprol-xl side effect: Sinus disorder (disease of sinus) (149 reports)
- Toprol-xl side effect: Hypophagia (reduced food intake) (148 reports)
- Toprol-xl side effect: Hepatic failure (liver failure) (146 reports)
- Toprol-xl side effect: Mental impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition) (145 reports)
- Toprol-xl side effect: Hypovolaemia (a decreased volume of circulating blood in the body) (144 reports)
- Toprol-xl side effect: Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints) (142 reports)
- Toprol-xl side effect: Aggression (139 reports)
- Toprol-xl side effect: Gastric disorder (disease of stomach) (136 reports)
- Toprol-xl side effect: Inflammation (135 reports)
- Toprol-xl side effect: Musculoskeletal chest pain (pain in chest muscle or nerve or bones) (133 reports)
- Toprol-xl side effect: Primary sequestrum (piece of dead bone that has become separated during the process of necrosis from normal/sound bone) (132 reports)
- Toprol-xl side effect: Joint stiffness (130 reports)
- Toprol-xl side effect: Gastroenteritis (inflammation of stomach and intestine) (129 reports)
- Toprol-xl side effect: Femur fracture (128 reports)
- Toprol-xl side effect: Discomfort (125 reports)
- Toprol-xl side effect: Cyst (a closed sac) (124 reports)
- Toprol-xl side effect: Haematemesis (vomiting of blood) (123 reports)
- Toprol-xl side effect: Feeling jittery (122 reports)
- Toprol-xl side effect: Tendonitis (a condition that causes pain and swelling of tendons) (121 reports)
- Toprol-xl side effect: Mitral valve prolapse (heart's mitral valve doesn't work well) (120 reports)
- Toprol-xl side effect: Abscess (pus) (119 reports)
- Toprol-xl side effect: Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness) (117 reports)
- Toprol-xl side effect: Cholecystitis (infection of gallbladder) (115 reports)
- Toprol-xl side effect: Eye swelling (113 reports)
- Toprol-xl side effect: Generalised oedema (swelling all over the body) (112 reports)
- Toprol-xl side effect: Parkinson's disease (111 reports)
- Toprol-xl side effect: Arterial occlusive disease (slow process through which arteries throughout the body become progressively narrowed and eventually completely blocked) (110 reports)
- Toprol-xl side effect: Mouth ulcers (109 reports)
- Toprol-xl side effect: Face oedema (swelling of face) (108 reports)
- Toprol-xl side effect: Vitreous floaters (spots before the eyes) (105 reports)
- Toprol-xl side effect: Hallucination, auditory (perceiving sounds without auditory stimulus) (104 reports)
- Toprol-xl side effect: Nodule (a growth of abnormal tissue) (103 reports)
- Toprol-xl side effect: Neuralgia (pain in one or more nerves) (101 reports)
Browse all side effects of Toprol-xl:
a b c d e f g h i j k l m n o p q r s t u v w x y zCommon drugs associated with Sinus node dysfunction:
- Aspirin (545 reports)
- Digoxin (318 reports)
- Furosemide (308 reports)
- Lasix (295 reports)
- Vioxx (236 reports)
- Avandia (232 reports)
- Coumadin (231 reports)
- Lipitor (205 reports)
- Lisinopril (193 reports)
- Atenolol (191 reports)
- Metformin (182 reports)
- Amlodipine (177 reports)
- Norvasc (171 reports)
- Simvastatin (165 reports)
- Fosamax (160 reports)
- Plavix (158 reports)
- Prednisone (146 reports)
- Allopurinol (138 reports)
- Omeprazole (135 reports)
- Diovan (131 reports)
- Spironolactone (130 reports)
- Aricept (111 reports)
- Prilosec (108 reports)
- Hydrochlorothiazide (107 reports)
- Zocor (106 reports)
- Carvedilol (105 reports)
- Tylenol (104 reports)
- Nexium (102 reports)
Browse all the drugs that are associated with Sinus node dysfunction:
- Sinus node dysfunction (1,178 drugs)
Common conditions associated with Sinus node dysfunction:
- Hypertension: 487 reports
- Hbp: 483 reports
- Auricular fibrillation: 337 reports
- Diabetes mellitus: 222 reports
- Diabetes: 221 reports
- Multiple myeloma: 169 reports
- Osteoporosis: 163 reports
- Thin bones: 153 reports
- Type 2 diabetes: 124 reports
Browse all the conditions that are associated with Sinus node dysfunction:
- Sinus node dysfunction (840 conditions)
Drugs similar to Toprol-xl and Sinus node dysfunction :
- Accupril and Sinus node dysfunction
- Adalat and Sinus node dysfunction
- Altace and Sinus node dysfunction
- Amlodipine and Sinus node dysfunction
- Amlodipine besylate and Sinus node dysfunction
- Amlodipine maleate; benazepril hydrochloride and Sinus node dysfunction
- Aspirin and Sinus node dysfunction
- Atacand and Sinus node dysfunction
- Atenolol and Sinus node dysfunction
- Atenolol and chlorthalidone and Sinus node dysfunction
- Avalide and Sinus node dysfunction
- Avapro and Sinus node dysfunction
- Azor and Sinus node dysfunction
- Benazepril hydrochloride and Sinus node dysfunction
- Benicar and Sinus node dysfunction
- Benicar hct and Sinus node dysfunction
- Bisoprolol fumarate and Sinus node dysfunction
- Bystolic and Sinus node dysfunction
- Candesartan cilexetil and Sinus node dysfunction
- Cardizem and Sinus node dysfunction
- Carvedilol and Sinus node dysfunction
- Chlorthalidone and Sinus node dysfunction
- Clonidine and Sinus node dysfunction
- Clonidine hydrochloride and Sinus node dysfunction
- Coreg and Sinus node dysfunction
- Cozaar and Sinus node dysfunction
- Diltiazem hydrochloride and Sinus node dysfunction
- Diovan and Sinus node dysfunction
- Diovan hct and Sinus node dysfunction
- Doxazosin mesylate and Sinus node dysfunction
- Dyazide and Sinus node dysfunction
- Enalapril maleate and Sinus node dysfunction
- Exforge and Sinus node dysfunction
- Felodipine and Sinus node dysfunction
- Furosemide and Sinus node dysfunction
- Hctz and Sinus node dysfunction
- Hydralazine hydrochloride and Sinus node dysfunction
- Hydrochlorothiazide and Sinus node dysfunction
- Hyzaar and Sinus node dysfunction
- Indapamide and Sinus node dysfunction
- Inderal and Sinus node dysfunction
- Irbesartan and Sinus node dysfunction
- Labetalol hydrochloride and Sinus node dysfunction
- Lasix and Sinus node dysfunction
- Lipitor and Sinus node dysfunction
- Lisinopril and Sinus node dysfunction
- Lisinopril and hydrochlorothiazide and Sinus node dysfunction
- Losartan and Sinus node dysfunction
- Losartan potassium and Sinus node dysfunction
- Losartan potassium; hydrochlorothiazide and Sinus node dysfunction
- Lotrel and Sinus node dysfunction
- Micardis and Sinus node dysfunction
- Micardis hct and Sinus node dysfunction
- Nifedipine and Sinus node dysfunction
- Norvasc and Sinus node dysfunction
- Olmesartan medoxomil and Sinus node dysfunction
- Perindopril erbumine and Sinus node dysfunction
- Propranolol hydrochloride and Sinus node dysfunction
- Quinapril and Sinus node dysfunction
- Ramipril and Sinus node dysfunction
- Spironolactone and Sinus node dysfunction
- Telmisartan and Sinus node dysfunction
- Tenormin and Sinus node dysfunction
- Triamterene and hydrochlorothiazide and Sinus node dysfunction
- Valsartan and Sinus node dysfunction
- Vasotec and Sinus node dysfunction
- Verapamil hcl and Sinus node dysfunction
- Verapamil hydrochloride and Sinus node dysfunction
- Zestril and Sinus node dysfunction
- Ziac and Sinus node dysfunction
- Zide and Sinus node dysfunction
How the study uses the data?
The study uses data from the FDA. It is based on metoprolol succinate (the active ingredients of Toprol-xl) and Toprol-xl (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
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