Advil cold and sinus vs. Excedrin: side effect and effectiveness comparison (a real world drug study)

Summary:

We compare the side effects and drug effectiveness of Advil cold and sinus and Excedrin. The phase IV clinical study is created by eHealthMe based on reports (from sources including the FDA) of 31,955 people who take Advil cold and sinus and Excedrin, and is updated regularly.

What is Advil cold and sinus?

Advil cold and sinus has active ingredients of ibuprofen; pseudoephedrine hydrochloride. It is often used in sinus headache. eHealthMe is studying from 1,673 Advil cold and sinus users. Check the latest studies of Advil cold and sinus.

What is Excedrin?

Excedrin has active ingredients of acetaminophen; aspirin; caffeine. It is often used in headache. eHealthMe is studying from 22,740 Excedrin users. Check the latest studies of Excedrin.



On Jul, 19, 2026

31,955 people who take Advil cold and sinus and Excedrin are studied.

Advil cold and sinus vs Excedrin drug comparison reports.

Drugs being compared in this study:

  • Excedrin (acetaminophen; aspirin; caffeine)
  • Advil Cold And Sinus (ibuprofen; pseudoephedrine hydrochloride)

Most common side effects of the drugs, overall:

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Most common side effects of the drugs, in long term (1+ years) use:

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Drug effectiveness:

Advil Cold And Sinus:

  • not at all: 1.35 %
  • somewhat: 22.97 %
  • moderate: 37.16 %
  • high: 29.73 %
  • very high: 8.78 %

Excedrin:

  • not at all: 2.15 %
  • somewhat: 19.35 %
  • moderate: 33.33 %
  • high: 29.84 %
  • very high: 15.32 %

Want to compare Advil cold and sinus with Excedrin?

- Personalize this study to your gender and age (0-99+)

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.



Related studies

Alternative drugs to, pros and cons of:

Browse all side effects of Advil cold and sinus:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Excedrin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study is based on ibuprofen; pseudoephedrine hydrochloride and acetaminophen; aspirin; caffeine (the active ingredients of Advil cold and sinus and Excedrin, respectively). Other drugs that have the same active ingredients (e.g. generic drugs or brand names) are also considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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