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Skelaxin vs. Orphenadrine citrate: side effect and effectiveness comparison (a real world drug study)

Summary:

We compare the side effects and drug effectiveness of Skelaxin and Orphenadrine citrate. The phase IV clinical study is created by eHealthMe based on reports (from sources including the FDA) of 18,165 people who take Skelaxin and Orphenadrine citrate, and is updated regularly.

What is Skelaxin?

Skelaxin has active ingredients of metaxalone. It is often used in back pain. eHealthMe is studying from 9,706 Skelaxin users. Check the latest studies of Skelaxin.

What is Orphenadrine citrate?

Orphenadrine citrate has active ingredients of orphenadrine citrate. It is often used in muscle aches. eHealthMe is studying from 1,189 Orphenadrine citrate users. Check the latest studies of Orphenadrine citrate.

On Jul, 20, 2026

18,165 people who take Skelaxin and Orphenadrine citrate are studied.

Skelaxin vs Orphenadrine citrate drug comparison reports.

Drugs being compared in this study:

  • Skelaxin (metaxalone)
  • Orphenadrine Citrate (orphenadrine citrate)

Most common side effects of the drugs, overall:

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Most common side effects of the drugs, in long term (1+ years) use:

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Drug effectiveness:

Skelaxin:

  • not at all: 3.5 %
  • somewhat: 39.09 %
  • moderate: 31.28 %
  • high: 21.4 %
  • very high: 4.73 %

Orphenadrine Citrate:

  • not at all: 7.52 %
  • somewhat: 27.07 %
  • moderate: 39.1 %
  • high: 22.56 %
  • very high: 3.76 %

Want to compare Skelaxin with Orphenadrine citrate?

- Personalize this study to your gender and age (0-99+)

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Related studies

Alternative drugs to, pros and cons of:

Browse all side effects of Skelaxin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Orphenadrine citrate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study is based on metaxalone and orphenadrine citrate (the active ingredients of Skelaxin and Orphenadrine citrate, respectively). Other drugs that have the same active ingredients (e.g. generic drugs or brand names) are also considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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