Lupron and Zanaflex drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lupron (leuprolide acetate) and Zanaflex (tizanidine hydrochloride). Common drug interactions include abdominal pain among females and full blood count decreased among males.

The phase IV clinical study analyzes what interactions people have when they take Lupron and Zanaflex. It is created by eHealthMe based on reports of 34 people who take the same drugs from the FDA, and is updated regularly.

What is Lupron?

Lupron has active ingredients of leuprolide acetate. It is often used in endometriosis. eHealthMe is studying from 42,122 Lupron users. Check the latest studies of Lupron.

What is Zanaflex?

Zanaflex has active ingredients of tizanidine hydrochloride. It is often used in muscle spasms. eHealthMe is studying from 17,476 Zanaflex users. Check the latest studies of Zanaflex.

On Jul, 12, 2026

34 people who take Lupron and Zanaflex together, and have interactions are studied.

What are the common drug interactions of Lupron and Zanaflex, by gender? *:

female:

Abdominal pain
Vaginal haemorrhage (vaginal bleeding)
Nausea (feeling of having an urge to vomit)
Abortion spontaneous (naturally occurring miscarriage)
Menorrhagia (an abnormally heavy bleeding and prolonged menstrual period at regular intervals)
Menstrual disorder (disease of menstrual cycle)
Polycystic ovaries (cysts in the ovaries that occurs when the follicle stops developing)
Uterine leiomyoma (uterine benign tumour derived from smooth muscle)
Abdominal pain lower
Depression

male:

Full blood count decreased
Ulcer haemorrhage (bleeding ulcer)
Blood iron decreased
Prostatic specific antigen increased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Pneumonia
Blood creatinine increased
Pain in extremity
Weight decreased

What are the common drug interactions of Lupron and Zanaflex, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abdominal pain lower
Headache (pain in head)
Hospitalisation
Increased appetite
Kidney infection
Maternal exposure before pregnancy (use of substance before pregnancy)
Nausea (feeling of having an urge to vomit)
Nephrolithiasis (calculi in the kidneys)
Pregnancy
Sleep disorder

30-39:

Throat tightness
Drug hypersensitivity
Mass
Arthralgia (joint pain)
Back pain
Headache (pain in head)
Influenza
Local swelling (swelling at the site of some application of substance or injury)
Menorrhagia (an abnormally heavy bleeding and prolonged menstrual period at regular intervals)
Migraine (headache)

40-49:

Abdominal pain
Abdominal pain upper
Anal haemorrhage
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Chest pain
Depression
Diarrhoea
Dizziness
Headache (pain in head)
Hepatic steatosis (fatty liver disease)

50-59:

Influenza like illness
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Headache (pain in head)

60+:

Full blood count decreased
Ulcer haemorrhage (bleeding ulcer)
Blood iron decreased
Prostatic specific antigen increased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Pneumonia
Blood creatinine increased
Pain in extremity
Weight decreased

What are the existing conditions these people have? *

High Blood Pressure: 6 people, 17.65%
Pain: 6 people, 17.65%
Stress And Anxiety: 6 people, 17.65%
Depression: 5 people, 14.71%
Prostate Cancer Metastatic: 5 people, 14.71%
Uterine Leiomyoma (uterine benign tumour derived from smooth muscle): 3 people, 8.82%
Nausea (feeling of having an urge to vomit): 3 people, 8.82%
Back Pain: 3 people, 8.82%
Metastases To Bone (cancer spreads to bone): 3 people, 8.82%
Neuralgia (pain in one or more nerves): 3 people, 8.82%

* Approximation only. Some reports may have incomplete information.

Do you take Lupron and Zanaflex?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously