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Xanax and Sinus node dysfunction - a phase IV clinical study of FDA data

Summary:

Sinus node dysfunction is reported as a side effect among people who take Xanax (alprazolam), especially for people who are male, 60+ old, also take Ambien, and have Constipation.

The phase IV clinical study analyzes which people have Sinus node dysfunction when taking Xanax. It is created by eHealthMe based on reports of 126,784 people who have side effects when taking Xanax from the FDA, and is updated regularly.

What is Xanax?

Xanax has active ingredients of alprazolam. It is often used in stress and anxiety. eHealthMe is studying from 135,334 Xanax users. Check the latest studies of Xanax.

What is Sinus node dysfunction?

Sinus node dysfunction (a group of abnormal heart rhythms) is found to be associated with 1,261 drugs and 834 conditions by eHealthMe. Check the latest studies of Sinus node dysfunction.

On Oct, 10, 2025

126,784 people reported to have side effects when taking Xanax.
Among them, 74 people (0.06%) have Sinus node dysfunction.

Could Xanax cause Sinus node dysfunction?

Among these 74 people:

What is the gender of people who have Sinus node dysfunction when taking Xanax? *

  • female: 43.66 %
  • male: 56.34 %

What is the age of people who have Sinus node dysfunction when taking Xanax? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 1.43 %
  • 30-39: 0.0 %
  • 40-49: 12.86 %
  • 50-59: 10.0 %
  • 60+: 75.71 %

What are other drugs people take besides Xanax? *

  1. Ambien: 29 people, 39.19%
  2. Prilosec: 25 people, 33.78%
  3. Aspirin: 25 people, 33.78%
  4. Zoloft: 24 people, 32.43%
  5. Flomax: 24 people, 32.43%
  6. Percocet: 23 people, 31.08%
  7. Coumadin: 23 people, 31.08%
  8. Toprol-Xl: 22 people, 29.73%
  9. Albuterol: 21 people, 28.38%
  10. Digoxin: 21 people, 28.38%

What are other side effects people have besides Sinus node dysfunction? *

  1. Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 47 people, 63.51%
  2. Fatigue (feeling of tiredness): 36 people, 48.65%
  3. Weakness: 34 people, 45.95%
  4. Nausea (feeling of having an urge to vomit): 28 people, 37.84%
  5. Pain: 26 people, 35.14%
  6. Depression: 26 people, 35.14%
  7. Back Pain: 25 people, 33.78%
  8. Visual Impairment: 24 people, 32.43%
  9. Weight Increased: 23 people, 31.08%
  10. Arthropathy: 22 people, 29.73%

What are the existing conditions these people have? *

  1. Constipation: 12 people, 16.22%
  2. Depression: 9 people, 12.16%
  3. Insomnia (sleeplessness): 6 people, 8.11%
  4. Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 6 people, 8.11%
  5. Nervousness: 6 people, 8.11%
  6. Cardiac Failure Congestive: 5 people, 6.76%
  7. Spondylosis (a defect of a vertebra): 4 people, 5.41%
  8. Pain: 3 people, 4.05%
  9. High Blood Pressure: 3 people, 4.05%
  10. Endometrial Cancer: 2 people, 2.70%

* Approximation only. Some reports may have incomplete information.

Do you take Xanax and have Sinus node dysfunction?

- Check whether Sinus node dysfunction is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Xanax:

  • Xanax (135,334 reports)

Sinus node dysfunction treatments and more:

How severe was Sinus node dysfunction and when was it recovered:

Expand to all the drugs that have ingredients of alprazolam:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Xanax:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Sinus node dysfunction:

Browse all the conditions that are associated with Sinus node dysfunction:

Drugs similar to Xanax and Sinus node dysfunction :

How the study uses the data?

The study uses data from the FDA. It is based on alprazolam (the active ingredients of Xanax) and Xanax (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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